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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
D2HGDH
All Species:
24.24
Human Site:
S178
Identified Species:
38.1
UniProt:
Q8N465
Number Species:
14
Phosphosite Substitution
Charge Score:
0.21
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N465
NP_689996.4
521
56416
S178
G
C
V
L
E
E
L
S
R
Y
V
E
E
R
D
Chimpanzee
Pan troglodytes
XP_001162772
466
50496
V156
S
T
A
R
M
N
R
V
L
S
F
H
S
V
S
Rhesus Macaque
Macaca mulatta
XP_001094865
519
56150
S176
G
C
V
L
E
E
L
S
H
Y
V
E
E
R
D
Dog
Lupus familis
XP_852029
541
59008
S198
G
C
I
L
E
E
L
S
Q
Y
V
E
A
R
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIM3
535
58556
S192
G
C
V
L
E
E
L
S
R
Y
V
Q
E
R
D
Rat
Rattus norvegicus
P84850
535
58786
S192
G
C
V
L
E
E
L
S
R
Y
V
Q
E
R
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422664
541
59236
N198
G
C
V
L
E
Q
L
N
E
Y
L
E
E
Q
G
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
A1L258
533
58696
S189
G
C
V
L
E
N
L
S
H
Y
L
E
E
R
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9V778
631
70803
E241
G
I
V
G
Q
D
L
E
R
V
L
R
S
E
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O45218
597
66541
E217
G
I
V
G
Q
S
L
E
R
Q
L
N
K
K
G
Sea Urchin
Strong. purpuratus
XP_783292
557
61383
D213
G
C
V
L
E
K
L
D
E
A
V
C
E
H
G
Poplar Tree
Populus trichocarpa
XP_002310828
530
58306
I184
G
C
I
L
E
N
L
I
S
Y
L
D
N
Q
G
Maize
Zea mays
NP_001141496
562
61260
S216
G
C
V
L
E
N
L
S
T
F
V
E
N
E
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O23240
559
61427
A212
G
C
I
L
E
N
L
A
T
F
L
D
T
K
G
Baker's Yeast
Sacchar. cerevisiae
P46681
530
59250
N180
G
V
I
L
E
N
A
N
N
Y
V
M
E
Q
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
95.5
78.9
N.A.
79.4
79.6
N.A.
N.A.
68.7
N.A.
61.7
N.A.
21.2
N.A.
20.4
53.5
Protein Similarity:
100
86.9
97.1
86.1
N.A.
86.7
87.2
N.A.
N.A.
81.1
N.A.
76.3
N.A.
37
N.A.
38.3
67.8
P-Site Identity:
100
0
93.3
73.3
N.A.
93.3
93.3
N.A.
N.A.
60
N.A.
80
N.A.
26.6
N.A.
26.6
53.3
P-Site Similarity:
100
0
93.3
86.6
N.A.
100
100
N.A.
N.A.
86.6
N.A.
86.6
N.A.
46.6
N.A.
53.3
60
Percent
Protein Identity:
52.2
50.8
N.A.
50.8
50.3
N.A.
Protein Similarity:
68.6
65.8
N.A.
65.6
66.6
N.A.
P-Site Identity:
40
60
N.A.
33.3
40
N.A.
P-Site Similarity:
66.6
66.6
N.A.
73.3
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
0
0
0
7
7
0
7
0
0
7
0
0
% A
% Cys:
0
74
0
0
0
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
0
0
0
0
7
0
7
0
0
0
14
0
0
34
% D
% Glu:
0
0
0
0
80
34
0
14
14
0
0
40
54
14
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
14
7
0
0
0
0
% F
% Gly:
94
0
0
14
0
0
0
0
0
0
0
0
0
0
54
% G
% His:
0
0
0
0
0
0
0
0
14
0
0
7
0
7
0
% H
% Ile:
0
14
27
0
0
0
0
7
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
7
0
0
0
0
0
0
7
14
0
% K
% Leu:
0
0
0
80
0
0
87
0
7
0
40
0
0
0
0
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
0
0
0
0
0
40
0
14
7
0
0
7
14
0
7
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
14
7
0
0
7
7
0
14
0
20
0
% Q
% Arg:
0
0
0
7
0
0
7
0
34
0
0
7
0
40
0
% R
% Ser:
7
0
0
0
0
7
0
47
7
7
0
0
14
0
7
% S
% Thr:
0
7
0
0
0
0
0
0
14
0
0
0
7
0
0
% T
% Val:
0
7
67
0
0
0
0
7
0
7
54
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
60
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _