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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RASGEF1C
All Species:
23.33
Human Site:
S246
Identified Species:
46.67
UniProt:
Q8N431
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N431
NP_778232.2
466
52870
S246
P
C
F
S
D
K
T
S
N
L
E
A
Y
V
K
Chimpanzee
Pan troglodytes
XP_518156
546
61226
S326
P
C
F
S
D
K
T
S
N
L
E
A
Y
V
K
Rhesus Macaque
Macaca mulatta
XP_001102791
466
52809
S246
P
C
F
S
D
K
T
S
H
L
E
A
Y
V
K
Dog
Lupus familis
XP_538583
684
76123
T313
P
C
F
S
E
K
T
T
N
L
E
A
Y
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q9D300
466
52705
N246
P
R
F
S
D
K
T
N
N
V
E
A
Y
V
K
Rat
Rattus norvegicus
NP_001101743
466
52800
N246
P
R
F
N
D
K
T
N
N
V
E
A
Y
V
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507622
522
60072
Y302
R
G
D
V
T
K
T
Y
T
L
E
A
Y
D
N
Chicken
Gallus gallus
XP_414615
480
55173
S260
C
F
S
D
Q
K
T
S
N
L
E
A
Y
V
K
Frog
Xenopus laevis
NP_001086251
419
48694
Y199
R
S
D
V
T
K
T
Y
N
L
E
A
Y
D
N
Zebra Danio
Brachydanio rerio
Q6DHR3
514
59871
S294
F
S
D
H
K
K
A
S
N
L
E
A
Y
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_396254
713
79278
R500
F
K
D
M
K
K
T
R
N
L
E
S
Y
I
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_789261
598
68657
K384
F
Q
D
L
K
R
T
K
N
L
E
A
Y
V
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85.1
98
63
N.A.
94.6
94.8
N.A.
51.3
81
50.4
62.8
N.A.
N.A.
37.3
N.A.
44.4
Protein Similarity:
100
85.1
98.9
66.2
N.A.
97.4
97.4
N.A.
66
87.9
65.4
73.9
N.A.
N.A.
48.3
N.A.
56.8
P-Site Identity:
100
100
93.3
86.6
N.A.
80
73.3
N.A.
40
66.6
46.6
53.3
N.A.
N.A.
40
N.A.
46.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
40
66.6
46.6
60
N.A.
N.A.
60
N.A.
60
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
0
0
0
0
92
0
0
0
% A
% Cys:
9
34
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
42
9
42
0
0
0
0
0
0
0
0
17
0
% D
% Glu:
0
0
0
0
9
0
0
0
0
0
100
0
0
0
17
% E
% Phe:
25
9
50
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
9
0
0
0
0
9
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
0
% I
% Lys:
0
9
0
0
25
92
0
9
0
0
0
0
0
0
59
% K
% Leu:
0
0
0
9
0
0
0
0
0
84
0
0
0
0
0
% L
% Met:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
9
0
0
0
17
84
0
0
0
0
0
17
% N
% Pro:
50
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
9
0
0
9
0
0
0
0
0
0
0
0
0
9
% Q
% Arg:
17
17
0
0
0
9
0
9
0
0
0
0
0
0
0
% R
% Ser:
0
17
9
42
0
0
0
42
0
0
0
9
0
0
0
% S
% Thr:
0
0
0
0
17
0
92
9
9
0
0
0
0
0
0
% T
% Val:
0
0
0
17
0
0
0
0
0
17
0
0
0
75
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
17
0
0
0
0
100
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _