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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
FBXW8
All Species:
8.79
Human Site:
T548
Identified Species:
21.48
UniProt:
Q8N3Y1
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8N3Y1
NP_036306.1
598
67297
T548
A
D
L
D
S
F
T
T
H
R
R
H
R
G
L
Chimpanzee
Pan troglodytes
XP_509407
597
67149
T547
A
D
L
D
S
F
T
T
H
R
R
H
R
G
L
Rhesus Macaque
Macaca mulatta
XP_001081979
598
67113
T548
V
D
L
D
S
F
T
T
H
R
R
H
R
G
L
Dog
Lupus familis
XP_543414
579
65284
N530
V
R
N
T
D
L
D
N
F
T
T
H
R
R
H
Cat
Felis silvestris
Mouse
Mus musculus
Q8BIA4
598
67937
C548
S
D
L
D
N
F
A
C
H
R
R
H
R
G
L
Rat
Rattus norvegicus
NP_001100615
326
36721
C276
S
D
L
D
N
F
A
C
H
R
R
H
R
G
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518259
219
24523
H170
T
D
D
D
L
T
A
H
R
R
H
R
G
I
I
Chicken
Gallus gallus
XP_415314
582
64892
L530
A
S
I
M
D
D
D
L
T
A
H
R
R
H
R
Frog
Xenopus laevis
NP_001085678
606
68247
L554
A
S
I
M
D
D
D
L
T
A
H
R
R
H
R
Zebra Danio
Brachydanio rerio
NP_001108050
627
70047
L572
A
C
I
T
D
D
D
L
T
A
H
R
R
Y
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
97.6
74.7
N.A.
78.7
43.6
N.A.
21.7
59.3
47.6
42.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
98.1
80.4
N.A.
86.9
48.1
N.A.
28.2
74.2
63.8
62.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
13.3
N.A.
73.3
73.3
N.A.
20
13.3
13.3
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
13.3
N.A.
86.6
86.6
N.A.
26.6
20
20
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
50
0
0
0
0
0
30
0
0
30
0
0
0
0
0
% A
% Cys:
0
10
0
0
0
0
0
20
0
0
0
0
0
0
0
% C
% Asp:
0
60
10
60
40
30
40
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
50
0
0
10
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
50
0
% G
% His:
0
0
0
0
0
0
0
10
50
0
40
60
0
20
10
% H
% Ile:
0
0
30
0
0
0
0
0
0
0
0
0
0
10
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
50
0
10
10
0
30
0
0
0
0
0
0
50
% L
% Met:
0
0
0
20
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
0
20
0
0
10
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
0
0
0
0
0
10
60
50
40
90
10
30
% R
% Ser:
20
20
0
0
30
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
10
0
0
20
0
10
30
30
30
10
10
0
0
0
0
% T
% Val:
20
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _