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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ABCA7
All Species:
4.24
Human Site:
S375
Identified Species:
8.48
UniProt:
Q8IZY2
Number Species:
11
Phosphosite Substitution
Charge Score:
0.73
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IZY2
NP_061985.2
2146
234350
S375
D
H
M
E
A
L
R
S
F
L
D
P
G
S
G
Chimpanzee
Pan troglodytes
XP_520163
2254
253166
D466
F
L
A
K
H
P
E
D
V
Q
S
S
N
G
S
Rhesus Macaque
Macaca mulatta
XP_001093459
2148
234326
S375
D
R
M
E
A
L
R
S
F
L
D
P
G
S
G
Dog
Lupus familis
XP_538773
2261
253895
D473
F
L
A
K
H
P
E
D
V
Q
S
A
N
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q91V24
2159
236865
D372
K
K
L
E
A
I
K
D
F
L
D
P
S
R
G
Rat
Rattus norvegicus
Q7TNJ2
2170
237702
D372
K
Q
L
E
A
I
R
D
F
L
D
P
S
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516009
2266
254238
D478
F
L
A
K
H
P
E
D
H
Q
S
S
N
G
S
Chicken
Gallus gallus
NP_989476
2260
254054
E474
F
L
S
K
H
P
E
E
F
E
A
D
N
G
M
Frog
Xenopus laevis
NP_001089022
2363
267334
D488
F
L
Y
N
G
N
P
D
E
R
P
E
G
Q
V
Zebra Danio
Brachydanio rerio
NP_001139161
2268
254351
E477
R
F
L
S
K
S
S
E
D
T
R
P
H
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34358
1704
191394
Y154
T
F
C
A
I
N
S
Y
A
A
G
V
V
F
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q84M24
1882
209045
Q331
W
F
I
T
Y
A
L
Q
F
A
L
C
S
G
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51
95.3
51.2
N.A.
77.6
77.4
N.A.
51
51.6
43.2
51.1
N.A.
N.A.
N.A.
25.5
N.A.
Protein Similarity:
100
67.4
96.9
67.4
N.A.
85.2
84.9
N.A.
67.5
67.7
61
68.4
N.A.
N.A.
N.A.
40.9
N.A.
P-Site Identity:
100
0
93.3
0
N.A.
46.6
53.3
N.A.
0
6.6
6.6
6.6
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
100
6.6
93.3
6.6
N.A.
66.6
66.6
N.A.
6.6
13.3
6.6
13.3
N.A.
N.A.
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
43.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
25
9
34
9
0
0
9
17
9
9
0
0
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
9
0
0
0
% C
% Asp:
17
0
0
0
0
0
0
50
9
0
34
9
0
0
9
% D
% Glu:
0
0
0
34
0
0
34
17
9
9
0
9
0
0
0
% E
% Phe:
42
25
0
0
0
0
0
0
50
0
0
0
0
9
0
% F
% Gly:
0
0
0
0
9
0
0
0
0
0
9
0
25
50
34
% G
% His:
0
9
0
0
34
0
0
0
9
0
0
0
9
0
0
% H
% Ile:
0
0
9
0
9
17
0
0
0
0
0
0
0
0
9
% I
% Lys:
17
9
0
34
9
0
9
0
0
0
0
0
0
0
0
% K
% Leu:
0
42
25
0
0
17
9
0
0
34
9
0
0
0
0
% L
% Met:
0
0
17
0
0
0
0
0
0
0
0
0
0
0
9
% M
% Asn:
0
0
0
9
0
17
0
0
0
0
0
0
34
0
0
% N
% Pro:
0
0
0
0
0
34
9
0
0
0
9
42
0
0
0
% P
% Gln:
0
9
0
0
0
0
0
9
0
25
0
0
0
9
0
% Q
% Arg:
9
9
0
0
0
0
25
0
0
9
9
0
0
17
0
% R
% Ser:
0
0
9
9
0
9
17
17
0
0
25
17
25
17
25
% S
% Thr:
9
0
0
9
0
0
0
0
0
9
0
0
0
0
9
% T
% Val:
0
0
0
0
0
0
0
0
17
0
0
9
9
0
9
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
9
0
9
0
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _