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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NALCN All Species: 23.03
Human Site: S781 Identified Species: 56.3
UniProt: Q8IZF0 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.22
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IZF0 NP_443099.1 1738 200331 S781 Q R I S R G K S L E T L T Q D
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001095394 946 108944 K138 E N H P Y F D K P L F I V G R
Dog Lupus familis XP_542654 1767 203659 S810 Q R I S R G K S L E T L T Q D
Cat Felis silvestris
Mouse Mus musculus Q8BXR5 1738 200423 S781 Q R I S R G K S L E T L T Q D
Rat Rattus norvegicus Q6Q760 1738 200472 S781 Q R I S R G K S L E T L T Q D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513665 1799 207525 S842 Q R I S R G K S L E T L T Q D
Chicken Gallus gallus XP_416967 1738 200228 S781 Q R I S R G K S L E T L T Q D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001096981 2232 246987 R1105 R S I R R S V R S G S I K L K
Honey Bee Apis mellifera XP_393620 1258 145688 S450 V V R L I K A S P M L E D F V
Nematode Worm Caenorhab. elegans NP_741413 1861 215037 G828 F N M Y S E N G D L S R P S D
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 53.7 97.5 N.A. 98.6 98.7 N.A. 94.7 96.8 N.A. N.A. N.A. 44.6 41.9 44.2 N.A.
Protein Similarity: 100 N.A. 54 98 N.A. 99.3 99.2 N.A. 95.8 98.2 N.A. N.A. N.A. 56.8 54 61.7 N.A.
P-Site Identity: 100 N.A. 0 100 N.A. 100 100 N.A. 100 100 N.A. N.A. N.A. 13.3 6.6 6.6 N.A.
P-Site Similarity: 100 N.A. 13.3 100 N.A. 100 100 N.A. 100 100 N.A. N.A. N.A. 33.3 6.6 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 10 0 10 0 0 0 10 0 70 % D
% Glu: 10 0 0 0 0 10 0 0 0 60 0 10 0 0 0 % E
% Phe: 10 0 0 0 0 10 0 0 0 0 10 0 0 10 0 % F
% Gly: 0 0 0 0 0 60 0 10 0 10 0 0 0 10 0 % G
% His: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 70 0 10 0 0 0 0 0 0 20 0 0 0 % I
% Lys: 0 0 0 0 0 10 60 10 0 0 0 0 10 0 10 % K
% Leu: 0 0 0 10 0 0 0 0 60 20 10 60 0 10 0 % L
% Met: 0 0 10 0 0 0 0 0 0 10 0 0 0 0 0 % M
% Asn: 0 20 0 0 0 0 10 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 10 0 0 0 0 20 0 0 0 10 0 0 % P
% Gln: 60 0 0 0 0 0 0 0 0 0 0 0 0 60 0 % Q
% Arg: 10 60 10 10 70 0 0 10 0 0 0 10 0 0 10 % R
% Ser: 0 10 0 60 10 10 0 70 10 0 20 0 0 10 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 60 0 60 0 0 % T
% Val: 10 10 0 0 0 0 10 0 0 0 0 0 10 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _