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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLL5 All Species: 16.67
Human Site: T786 Identified Species: 45.83
UniProt: Q8IZD2 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IZD2 NP_061152.3 1858 204965 T786 Y S P H V Y S T P K H Y I R F
Chimpanzee Pan troglodytes XP_516258 1426 155894 T378 I Y A V S A I T K D A E V T I
Rhesus Macaque Macaca mulatta XP_001092500 1474 160966 S426 I A F D Y E Y S N C N Y K V D
Dog Lupus familis XP_533102 1932 213103 T786 Y S P H V Y S T P K H Y I R F
Cat Felis silvestris
Mouse Mus musculus Q3UG20 1868 204525 T786 Y S P H V Y S T P K H Y I R F
Rat Rattus norvegicus XP_001059647 1856 203523 T786 Y S P H V Y S T P K H Y I R F
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508126 1444 158267 Y396 T I G F D F E Y S N C N Y K V
Chicken Gallus gallus XP_001233428 1446 157725 A398 M I H L C I Y A V A T I A K D
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_692965 1479 159478 Y430 E E G M L H L Y I Y S L R S I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.1 28.4 87.5 N.A. 89.1 88.6 N.A. 24.8 27 N.A. 43.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 42.4 43.1 90.4 N.A. 93.3 93 N.A. 40.5 41.5 N.A. 54.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 6.6 6.6 100 N.A. 100 100 N.A. 0 0 N.A. 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 13.3 26.6 100 N.A. 100 100 N.A. 13.3 6.6 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 12 12 0 0 12 0 12 0 12 12 0 12 0 0 % A
% Cys: 0 0 0 0 12 0 0 0 0 12 12 0 0 0 0 % C
% Asp: 0 0 0 12 12 0 0 0 0 12 0 0 0 0 23 % D
% Glu: 12 12 0 0 0 12 12 0 0 0 0 12 0 0 0 % E
% Phe: 0 0 12 12 0 12 0 0 0 0 0 0 0 0 45 % F
% Gly: 0 0 23 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 12 45 0 12 0 0 0 0 45 0 0 0 0 % H
% Ile: 23 23 0 0 0 12 12 0 12 0 0 12 45 0 23 % I
% Lys: 0 0 0 0 0 0 0 0 12 45 0 0 12 23 0 % K
% Leu: 0 0 0 12 12 0 12 0 0 0 0 12 0 0 0 % L
% Met: 12 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 12 12 12 12 0 0 0 % N
% Pro: 0 0 45 0 0 0 0 0 45 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 12 45 0 % R
% Ser: 0 45 0 0 12 0 45 12 12 0 12 0 0 12 0 % S
% Thr: 12 0 0 0 0 0 0 56 0 0 12 0 0 12 0 % T
% Val: 0 0 0 12 45 0 0 0 12 0 0 0 12 12 12 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 45 12 0 0 12 45 23 23 0 12 0 56 12 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _