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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MLL5 All Species: 14.24
Human Site: S932 Identified Species: 39.17
UniProt: Q8IZD2 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IZD2 NP_061152.3 1858 204965 S932 N G Y K P I Y S P V T P V T P
Chimpanzee Pan troglodytes XP_516258 1426 155894 E524 M H A F E N L E K R K K R R D
Rhesus Macaque Macaca mulatta XP_001092500 1474 160966 N572 D Q P L E Q S N S D V E I N T
Dog Lupus familis XP_533102 1932 213103 S932 N G Y K P I Y S P V T P V T P
Cat Felis silvestris
Mouse Mus musculus Q3UG20 1868 204525 S932 N G Y K P I Y S P V T P V T P
Rat Rattus norvegicus XP_001059647 1856 203523 S932 N S Y K P I Y S P V T P V T P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508126 1444 158267 S542 E Q P L E R S S T S L E A T P
Chicken Gallus gallus XP_001233428 1446 157725 N544 A I M H M F E N L E K R K R R
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_692965 1479 159478 R576 R K M T R E E R K M E A I L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 27.1 28.4 87.5 N.A. 89.1 88.6 N.A. 24.8 27 N.A. 43.7 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 42.4 43.1 90.4 N.A. 93.3 93 N.A. 40.5 41.5 N.A. 54.9 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 0 0 100 N.A. 100 93.3 N.A. 20 0 N.A. 0 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 0 20 100 N.A. 100 93.3 N.A. 20 6.6 N.A. 13.3 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 12 0 12 0 0 0 0 0 0 0 0 12 12 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 12 0 0 0 0 0 0 0 0 12 0 0 0 0 12 % D
% Glu: 12 0 0 0 34 12 23 12 0 12 12 23 0 0 0 % E
% Phe: 0 0 0 12 0 12 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 34 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 12 0 12 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 12 0 0 0 45 0 0 0 0 0 0 23 0 0 % I
% Lys: 0 12 0 45 0 0 0 0 23 0 23 12 12 0 0 % K
% Leu: 0 0 0 23 0 0 12 0 12 0 12 0 0 12 0 % L
% Met: 12 0 23 0 12 0 0 0 0 12 0 0 0 0 0 % M
% Asn: 45 0 0 0 0 12 0 23 0 0 0 0 0 12 0 % N
% Pro: 0 0 23 0 45 0 0 0 45 0 0 45 0 0 56 % P
% Gln: 0 23 0 0 0 12 0 0 0 0 0 0 0 0 12 % Q
% Arg: 12 0 0 0 12 12 0 12 0 12 0 12 12 23 12 % R
% Ser: 0 12 0 0 0 0 23 56 12 12 0 0 0 0 0 % S
% Thr: 0 0 0 12 0 0 0 0 12 0 45 0 0 56 12 % T
% Val: 0 0 0 0 0 0 0 0 0 45 12 0 45 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 45 0 0 0 45 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _