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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MLL5
All Species:
1.82
Human Site:
S1405
Identified Species:
5
UniProt:
Q8IZD2
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IZD2
NP_061152.3
1858
204965
S1405
E
L
Q
Q
K
Q
L
S
N
N
N
Q
A
L
S
Chimpanzee
Pan troglodytes
XP_516258
1426
155894
L997
A
M
P
R
A
D
G
L
Y
R
G
S
P
L
V
Rhesus Macaque
Macaca mulatta
XP_001092500
1474
160966
H1045
V
G
D
R
K
P
L
H
L
D
G
G
Y
C
S
Dog
Lupus familis
XP_533102
1932
213103
L1405
E
V
H
P
K
Q
L
L
S
N
T
Q
A
L
A
Cat
Felis silvestris
Mouse
Mus musculus
Q3UG20
1868
204525
Q1405
V
H
Q
N
P
E
P
Q
H
R
Q
L
S
S
N
Rat
Rattus norvegicus
XP_001059647
1856
203523
P1405
K
Q
L
S
S
N
T
P
A
L
S
K
N
H
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508126
1444
158267
S1015
G
D
R
K
P
F
I
S
D
R
G
Y
C
G
S
Chicken
Gallus gallus
XP_001233428
1446
157725
R1017
P
R
V
D
G
L
L
R
G
S
A
C
L
G
D
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_692965
1479
159478
P1049
M
A
V
D
P
P
A
P
A
A
T
P
T
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
27.1
28.4
87.5
N.A.
89.1
88.6
N.A.
24.8
27
N.A.
43.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
42.4
43.1
90.4
N.A.
93.3
93
N.A.
40.5
41.5
N.A.
54.9
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
20
53.3
N.A.
6.6
0
N.A.
13.3
6.6
N.A.
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
33.3
73.3
N.A.
33.3
20
N.A.
40
13.3
N.A.
0
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
12
0
0
12
0
12
0
23
12
12
0
23
0
12
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
12
12
12
0
% C
% Asp:
0
12
12
23
0
12
0
0
12
12
0
0
0
0
12
% D
% Glu:
23
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% F
% Gly:
12
12
0
0
12
0
12
0
12
0
34
12
0
23
0
% G
% His:
0
12
12
0
0
0
0
12
12
0
0
0
0
12
0
% H
% Ile:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% I
% Lys:
12
0
0
12
34
0
0
0
0
0
0
12
0
0
0
% K
% Leu:
0
12
12
0
0
12
45
23
12
12
0
12
12
34
0
% L
% Met:
12
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
12
0
12
0
0
12
23
12
0
12
0
12
% N
% Pro:
12
0
12
12
34
23
12
23
0
0
0
12
12
12
12
% P
% Gln:
0
12
23
12
0
23
0
12
0
0
12
23
0
0
0
% Q
% Arg:
0
12
12
23
0
0
0
12
0
34
0
0
0
0
12
% R
% Ser:
0
0
0
12
12
0
0
23
12
12
12
12
12
12
34
% S
% Thr:
0
0
0
0
0
0
12
0
0
0
23
0
12
0
0
% T
% Val:
23
12
23
0
0
0
0
0
0
0
0
0
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
12
0
0
12
12
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _