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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALDH16A1 All Species: 8.48
Human Site: S498 Identified Species: 18.67
UniProt: Q8IZ83 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IZ83 NP_699160.2 802 85127 S498 P A R L S C L S K N L N Y D T
Chimpanzee Pan troglodytes XP_001172626 802 85017 S498 P A Q L S C L S K N L N Y D T
Rhesus Macaque Macaca mulatta XP_001113116 323 33722 T75 V V A S P F R T A K E A L A L
Dog Lupus familis XP_851694 802 85494 S498 P G R L A Y F S E S M N Y D T
Cat Felis silvestris
Mouse Mus musculus Q571I9 802 84737 C498 P S Q E S F L C E N I N Y D T
Rat Rattus norvegicus Q3T1L0 802 85396 C498 P Y R E S F L C E S L N Y D T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001519604 638 66871 D390 Y P P T L I T D L P A A S P C
Chicken Gallus gallus
Frog Xenopus laevis NP_001089655 811 89363 G488 S R P Q P N P G E L N Y K T F
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_797815 831 90903 V512 E K K K P G N V D M E L K L F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9S795 501 54413 L253 V M T A A A Q L V K P V S M E
Baker's Yeast Sacchar. cerevisiae P40047 520 56602 G271 F T G S T A T G R H I M K V A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.2 38.7 84.9 N.A. 81.8 81 N.A. 49.2 N.A. 43.6 N.A. N.A. N.A. N.A. N.A. 41.1
Protein Similarity: 100 99.2 39.4 90.9 N.A. 88 87.9 N.A. 60.8 N.A. 61.1 N.A. N.A. N.A. N.A. N.A. 60.2
P-Site Identity: 100 93.3 0 53.3 N.A. 53.3 60 N.A. 0 N.A. 0 N.A. N.A. N.A. N.A. N.A. 0
P-Site Similarity: 100 100 6.6 80 N.A. 80 73.3 N.A. 0 N.A. 6.6 N.A. N.A. N.A. N.A. N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. 21 21.4 N.A.
Protein Similarity: N.A. N.A. N.A. 32.4 35.6 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 19 10 10 19 19 0 0 10 0 10 19 0 10 10 % A
% Cys: 0 0 0 0 0 19 0 19 0 0 0 0 0 0 10 % C
% Asp: 0 0 0 0 0 0 0 10 10 0 0 0 0 46 0 % D
% Glu: 10 0 0 19 0 0 0 0 37 0 19 0 0 0 10 % E
% Phe: 10 0 0 0 0 28 10 0 0 0 0 0 0 0 19 % F
% Gly: 0 10 10 0 0 10 0 19 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 10 0 0 0 0 19 0 0 0 0 % I
% Lys: 0 10 10 10 0 0 0 0 19 19 0 0 28 0 0 % K
% Leu: 0 0 0 28 10 0 37 10 10 10 28 10 10 10 10 % L
% Met: 0 10 0 0 0 0 0 0 0 10 10 10 0 10 0 % M
% Asn: 0 0 0 0 0 10 10 0 0 28 10 46 0 0 0 % N
% Pro: 46 10 19 0 28 0 10 0 0 10 10 0 0 10 0 % P
% Gln: 0 0 19 10 0 0 10 0 0 0 0 0 0 0 0 % Q
% Arg: 0 10 28 0 0 0 10 0 10 0 0 0 0 0 0 % R
% Ser: 10 10 0 19 37 0 0 28 0 19 0 0 19 0 0 % S
% Thr: 0 10 10 10 10 0 19 10 0 0 0 0 0 10 46 % T
% Val: 19 10 0 0 0 0 0 10 10 0 0 10 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 10 0 0 0 10 0 0 0 0 0 10 46 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _