KinATLAS
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PhosphoNET
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DrugKiNET
KiNET-AM
Kinector
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DIS3L2
All Species:
7.27
Human Site:
S48
Identified Species:
11.43
UniProt:
Q8IYB7
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8IYB7
NP_689596.4
885
99210
S48
S
T
R
G
K
K
K
S
I
F
E
T
Y
M
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001114025
580
64957
Dog
Lupus familis
XP_852722
879
98718
Y51
K
K
S
V
F
E
T
Y
M
S
K
E
D
V
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8CI75
870
97756
S48
S
M
R
G
K
K
K
S
I
F
E
T
Y
M
S
Rat
Rattus norvegicus
Q5U2P0
1054
120741
H57
L
L
S
A
E
V
T
H
Y
V
I
P
D
W
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_422741
859
96810
Y48
K
K
S
I
F
E
A
Y
M
S
K
E
D
V
S
Frog
Xenopus laevis
Q6GN11
1040
119148
Q63
V
P
D
C
Q
V
L
Q
D
Y
Q
E
V
L
E
Zebra Danio
Brachydanio rerio
A2RV18
1057
120333
E130
Y
C
P
R
E
K
G
E
S
Q
D
K
W
H
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_728490
1044
118207
Q48
A
A
R
L
Q
Q
M
Q
R
E
M
E
S
N
A
Honey Bee
Apis mellifera
XP_624734
786
91013
V48
K
T
T
D
K
Q
S
V
H
L
D
S
E
E
R
Nematode Worm
Caenorhab. elegans
Q09568
817
93710
G50
T
D
A
G
I
E
D
G
S
M
F
K
G
V
L
Sea Urchin
Strong. purpuratus
XP_001188256
807
90270
L48
M
S
T
P
R
K
L
L
A
N
Q
P
I
I
A
Poplar Tree
Populus trichocarpa
XP_002302251
860
96450
K60
F
E
G
Q
A
Q
S
K
I
F
A
P
Y
W
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_177891
1055
116824
K146
I
E
G
S
S
Q
R
K
I
F
S
S
H
W
S
Baker's Yeast
Sacchar. cerevisiae
Q08162
1001
113688
L194
P
Y
D
I
N
V
V
L
V
T
N
D
R
L
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.9
89.4
N.A.
85.9
26
N.A.
N.A.
70.4
25.5
25.5
N.A.
29.2
30.3
38.8
43
Protein Similarity:
100
N.A.
64.5
94.1
N.A.
91.5
43.3
N.A.
N.A.
82.3
43.2
42.1
N.A.
46
49.9
58.8
57.8
P-Site Identity:
100
N.A.
0
6.6
N.A.
93.3
0
N.A.
N.A.
6.6
0
6.6
N.A.
6.6
13.3
6.6
6.6
P-Site Similarity:
100
N.A.
0
33.3
N.A.
93.3
6.6
N.A.
N.A.
33.3
26.6
33.3
N.A.
33.3
33.3
26.6
40
Percent
Protein Identity:
33.9
N.A.
N.A.
30.2
28.3
N.A.
Protein Similarity:
49.9
N.A.
N.A.
46
44.7
N.A.
P-Site Identity:
26.6
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
46.6
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
7
7
7
0
7
0
7
0
7
0
0
0
14
% A
% Cys:
0
7
0
7
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
14
7
0
0
7
0
7
0
14
7
20
0
0
% D
% Glu:
0
14
0
0
14
20
0
7
0
7
14
27
7
7
7
% E
% Phe:
7
0
0
0
14
0
0
0
0
27
7
0
0
0
0
% F
% Gly:
0
0
14
20
0
0
7
7
0
0
0
0
7
0
0
% G
% His:
0
0
0
0
0
0
0
7
7
0
0
0
7
7
0
% H
% Ile:
7
0
0
14
7
0
0
0
27
0
7
0
7
7
0
% I
% Lys:
20
14
0
0
20
27
14
14
0
0
14
14
0
0
7
% K
% Leu:
7
7
0
7
0
0
14
14
0
7
0
0
0
14
7
% L
% Met:
7
7
0
0
0
0
7
0
14
7
7
0
0
14
0
% M
% Asn:
0
0
0
0
7
0
0
0
0
7
7
0
0
7
7
% N
% Pro:
7
7
7
7
0
0
0
0
0
0
0
20
0
0
0
% P
% Gln:
0
0
0
7
14
27
0
14
0
7
14
0
0
0
0
% Q
% Arg:
0
0
20
7
7
0
7
0
7
0
0
0
7
0
7
% R
% Ser:
14
7
20
7
7
0
14
14
14
14
7
14
7
0
40
% S
% Thr:
7
14
14
0
0
0
14
0
0
7
0
14
0
0
7
% T
% Val:
7
0
0
7
0
20
7
7
7
7
0
0
7
20
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
7
20
0
% W
% Tyr:
7
7
0
0
0
0
0
14
7
7
0
0
20
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _