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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHX37 All Species: 18.18
Human Site: S169 Identified Species: 36.36
UniProt: Q8IY37 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IY37 NP_116045.2 1157 129545 S169 E E E E E E E S E S E L E E E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001103101 1146 127695 S168 E E E E S Q E S E L E G E S E
Dog Lupus familis XP_534640 1149 128641 S169 E S E P S M E S E P E E A P A
Cat Felis silvestris
Mouse Mus musculus Q8VHK9 1001 113864 Q136 S E K K L D N Q E K K L L N Q
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508258 1135 128020 S167 E A G E Q T A S E Q T V I E E
Chicken Gallus gallus XP_415104 1141 127222 S170 P E G E S S G S E E E K K E E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001076473 1152 129559 S170 E E N E S E M S E S S E D D D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O46072 1192 134102 N179 Q A K R K N P N V I S V E E D
Honey Bee Apis mellifera XP_001121639 1118 128185 N168 L E S D T K N N E D E Q E E N
Nematode Worm Caenorhab. elegans P34305 1148 129944 N163 N D I E D A G N T V E V K I E
Sea Urchin Strong. purpuratus XP_786550 1324 147742 S242 D N K A R T K S E S D N V V K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q04217 1267 144936 S272 E M D F D T T S E D D D E E E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 94.4 86.5 N.A. 23.1 N.A. N.A. 73.1 72.1 N.A. 66.2 N.A. 45.5 48.1 41.4 49.4
Protein Similarity: 100 N.A. 96.1 92 N.A. 42.2 N.A. N.A. 84 83.4 N.A. 78.8 N.A. 63.3 66.6 57.3 63.9
P-Site Identity: 100 N.A. 66.6 40 N.A. 20 N.A. N.A. 40 46.6 N.A. 46.6 N.A. 13.3 33.3 20 20
P-Site Similarity: 100 N.A. 73.3 40 N.A. 53.3 N.A. N.A. 53.3 53.3 N.A. 66.6 N.A. 53.3 53.3 53.3 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 33.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 50.8 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 40 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 60 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 17 0 9 0 9 9 0 0 0 0 0 9 0 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 9 9 9 17 9 0 0 0 17 17 9 9 9 17 % D
% Glu: 50 50 25 50 9 17 25 0 84 9 50 17 42 50 50 % E
% Phe: 0 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 17 0 0 0 17 0 0 0 0 9 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 9 0 0 0 0 0 0 9 0 0 9 9 0 % I
% Lys: 0 0 25 9 9 9 9 0 0 9 9 9 17 0 9 % K
% Leu: 9 0 0 0 9 0 0 0 0 9 0 17 9 0 0 % L
% Met: 0 9 0 0 0 9 9 0 0 0 0 0 0 0 0 % M
% Asn: 9 9 9 0 0 9 17 25 0 0 0 9 0 9 9 % N
% Pro: 9 0 0 9 0 0 9 0 0 9 0 0 0 9 0 % P
% Gln: 9 0 0 0 9 9 0 9 0 9 0 9 0 0 9 % Q
% Arg: 0 0 0 9 9 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 9 9 0 34 9 0 67 0 25 17 0 0 9 0 % S
% Thr: 0 0 0 0 9 25 9 0 9 0 9 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 9 9 0 25 9 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _