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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PNPLA6 All Species: 17.88
Human Site: S411 Identified Species: 35.76
UniProt: Q8IY17 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IY17 NP_006693.3 1366 149995 S411 P L L S R C V S M P G D I S G
Chimpanzee Pan troglodytes XP_512331 1484 162976 S529 P L L S R C V S M P G D I S G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542111 1474 161798 S531 P L L S R C I S M P V D I S D
Cat Felis silvestris
Mouse Mus musculus Q3TRM4 1355 149519 S405 P L L S R C I S M P V D I S G
Rat Rattus norvegicus Q5BK26 1349 150006 G395 D E L R Q A Q G S G S N T S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001106924 1321 147821 S383 P L L S R C I S M P V D I S G
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001921208 1348 150755 F395 Q K S L R S D F D M A Y E R G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9U969 1425 160554 N399 E H T L S D P N P N P D G S F
Honey Bee Apis mellifera XP_001120383 1324 149002 D360 T T I S S E H D K N E I V H I
Nematode Worm Caenorhab. elegans Q02331 1353 152377 V369 W I R P I Q I V I T R L L H V
Sea Urchin Strong. purpuratus XP_001202094 1454 161991 K452 E E A T D V F K S A R V L G P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7S8J1 1515 167542 S517 A Y S K R R Q S I V T A T P A
Conservation
Percent
Protein Identity: 100 89 N.A. 88.1 N.A. 94.3 59.2 N.A. N.A. 77.1 N.A. 71.2 N.A. 40 45.2 33.1 43.9
Protein Similarity: 100 89.7 N.A. 90.2 N.A. 96.1 71.5 N.A. N.A. 84.7 N.A. 81.7 N.A. 58.1 61.4 51 60.8
P-Site Identity: 100 100 N.A. 80 N.A. 86.6 13.3 N.A. N.A. 86.6 N.A. 13.3 N.A. 13.3 6.6 0 0
P-Site Similarity: 100 100 N.A. 86.6 N.A. 93.3 26.6 N.A. N.A. 93.3 N.A. 13.3 N.A. 20 20 26.6 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 28.7
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 45
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 9 0 0 9 0 0 0 9 9 9 0 0 17 % A
% Cys: 0 0 0 0 0 42 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 9 9 9 9 9 0 0 50 0 0 9 % D
% Glu: 17 17 0 0 0 9 0 0 0 0 9 0 9 0 0 % E
% Phe: 0 0 0 0 0 0 9 9 0 0 0 0 0 0 9 % F
% Gly: 0 0 0 0 0 0 0 9 0 9 17 0 9 9 42 % G
% His: 0 9 0 0 0 0 9 0 0 0 0 0 0 17 0 % H
% Ile: 0 9 9 0 9 0 34 0 17 0 0 9 42 0 9 % I
% Lys: 0 9 0 9 0 0 0 9 9 0 0 0 0 0 0 % K
% Leu: 0 42 50 17 0 0 0 0 0 0 0 9 17 0 0 % L
% Met: 0 0 0 0 0 0 0 0 42 9 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 9 0 17 0 9 0 0 0 % N
% Pro: 42 0 0 9 0 0 9 0 9 42 9 0 0 9 9 % P
% Gln: 9 0 0 0 9 9 17 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 9 9 59 9 0 0 0 0 17 0 0 9 0 % R
% Ser: 0 0 17 50 17 9 0 50 17 0 9 0 0 59 0 % S
% Thr: 9 9 9 9 0 0 0 0 0 9 9 0 17 0 0 % T
% Val: 0 0 0 0 0 9 17 9 0 9 25 9 9 0 9 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 9 0 0 0 0 0 0 0 0 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _