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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ZC3H3 All Species: 11.21
Human Site: S617 Identified Species: 22.42
UniProt: Q8IXZ2 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IXZ2 NP_055932.2 948 101930 S617 K V S A N K L S K T S G Q P S
Chimpanzee Pan troglodytes XP_519998 1257 135558 S922 K V S A N K L S K T S G Q P S
Rhesus Macaque Macaca mulatta XP_001097060 1074 115065 S745 K V S A N K L S K T S G Q P G
Dog Lupus familis XP_539198 1016 109897 K681 V S A N K L S K T Y S R P S G
Cat Felis silvestris
Mouse Mus musculus Q8CHP0 950 103206 K614 V S A N K L S K T S S R P S D
Rat Rattus norvegicus NP_001128337 952 103496 K615 V S A N K L S K T S S R P S D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001518934 951 103158 L608 R A K S S P V L K K N P N R G
Chicken Gallus gallus NP_001026756 956 105809 P627 L S K T S S T P G R C R D L S
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_689680 929 101372 S592 I H H N P A L S Y R V K R V H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648230 597 66304 S280 R T L Q R T L S G R T L F V S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785788 1142 125989 G785 K S L R R I S G S S P I L P S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q3ED78 470 53750 F153 A R E R V F R F G S L R Y K M
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 73.8 82.8 70.8 N.A. 70.6 70.6 N.A. 47.7 42.4 N.A. 36.3 N.A. 22.4 N.A. N.A. 25.6
Protein Similarity: 100 74.4 84.3 77.9 N.A. 79.5 79.3 N.A. 57.2 56.2 N.A. 52 N.A. 37.2 N.A. N.A. 38.7
P-Site Identity: 100 100 93.3 6.6 N.A. 6.6 6.6 N.A. 6.6 6.6 N.A. 13.3 N.A. 20 N.A. N.A. 20
P-Site Similarity: 100 100 93.3 13.3 N.A. 20 20 N.A. 40 13.3 N.A. 20 N.A. 33.3 N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. 21.5 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 32.7 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 25 25 0 9 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 17 % D
% Glu: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 9 0 9 0 0 0 0 9 0 0 % F
% Gly: 0 0 0 0 0 0 0 9 25 0 0 25 0 0 25 % G
% His: 0 9 9 0 0 0 0 0 0 0 0 0 0 0 9 % H
% Ile: 9 0 0 0 0 9 0 0 0 0 0 9 0 0 0 % I
% Lys: 34 0 17 0 25 25 0 25 34 9 0 9 0 9 0 % K
% Leu: 9 0 17 0 0 25 42 9 0 0 9 9 9 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % M
% Asn: 0 0 0 34 25 0 0 0 0 0 9 0 9 0 0 % N
% Pro: 0 0 0 0 9 9 0 9 0 0 9 9 25 34 0 % P
% Gln: 0 0 0 9 0 0 0 0 0 0 0 0 25 0 0 % Q
% Arg: 17 9 0 17 17 0 9 0 0 25 0 42 9 9 0 % R
% Ser: 0 42 25 9 17 9 34 42 9 34 50 0 0 25 42 % S
% Thr: 0 9 0 9 0 9 9 0 25 25 9 0 0 0 0 % T
% Val: 25 25 0 0 9 0 9 0 0 0 9 0 0 17 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 9 9 0 0 9 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _