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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LRRC8A All Species: 27.27
Human Site: Y108 Identified Species: 66.67
UniProt: Q8IWT6 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IWT6 NP_001120716.1 810 94199 Y108 L D R H Q Y N Y V D A V C Y E
Chimpanzee Pan troglodytes XP_001160980 841 97525 Y139 L D R H Q Y N Y V D A V C Y E
Rhesus Macaque Macaca mulatta XP_001109419 754 87489 Y108 L D R H Q Y N Y V D A V C Y E
Dog Lupus familis XP_548430 810 94076 Y108 L D R H Q Y N Y V D A V C Y E
Cat Felis silvestris
Mouse Mus musculus Q80WG5 810 94101 Y108 L D R H Q Y N Y V D A V C Y E
Rat Rattus norvegicus Q4V8I7 810 94143 Y108 L D R H Q Y N Y V D A V C Y E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514421 809 93645 V108 D R H Q Y N Y V D A V C Y E N
Chicken Gallus gallus XP_415484 810 94346 Y108 L D R H Q Y N Y V D A V C Y E
Frog Xenopus laevis Q6NU09 806 92226 F115 L D L Q Q Y S F I N Q M C Y E
Zebra Danio Brachydanio rerio XP_686175 796 93027 F108 Y E N R L H W F A K Y F P Y L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 95 90.1 98.8 N.A. 99 98.6 N.A. 93.4 94.9 55.1 85.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 95.4 90.8 99.3 N.A. 99.3 99.1 N.A. 97.5 97.5 71.1 91.8 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 0 100 46.6 6.6 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 0 100 80 26.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 10 10 70 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 10 80 0 0 % C
% Asp: 10 80 0 0 0 0 0 0 10 70 0 0 0 0 0 % D
% Glu: 0 10 0 0 0 0 0 0 0 0 0 0 0 10 80 % E
% Phe: 0 0 0 0 0 0 0 20 0 0 0 10 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 10 70 0 10 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % K
% Leu: 80 0 10 0 10 0 0 0 0 0 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % M
% Asn: 0 0 10 0 0 10 70 0 0 10 0 0 0 0 10 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % P
% Gln: 0 0 0 20 80 0 0 0 0 0 10 0 0 0 0 % Q
% Arg: 0 10 70 10 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 10 70 0 10 70 0 0 0 % V
% Trp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 0 10 80 10 70 0 0 10 0 10 90 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _