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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: BRSK2 All Species: 10.3
Human Site: S427 Identified Species: 25.19
UniProt: Q8IWQ3 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q8IWQ3 NP_003948.2 736 81633 S427 L S T S P L S S P R V T P H P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_850919 676 75195 S367 L S T S P L S S P R V T P H P
Cat Felis silvestris
Mouse Mus musculus Q69Z98 735 81715 S428 L S T S P L S S P R V T P H P
Rat Rattus norvegicus Q8VHF0 797 88733 S469 G K G I A P A S P M L G N A S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q9IA88 798 88848 V447 E T T I S E E V R Q E K E L E
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q6NSM8 1187 130949 P736 L M Q T H G G P S A V Q Y Q H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648814 861 95238 H543 S A S P S V H H R A N S G P T
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9TW45 1192 126331 A705 I P S H R D H A Q Q Q Q Y M N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P92958 512 58671 L208 V W S C G V I L Y A L L C G T
Baker's Yeast Sacchar. cerevisiae P34244 1518 169574 N600 R R S L R L S N S R L S L S A
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. 89.8 N.A. 97.9 25.4 N.A. N.A. 27.4 N.A. 25.1 N.A. 50.9 N.A. 23.1 N.A.
Protein Similarity: 100 N.A. N.A. 90.3 N.A. 98.7 43.2 N.A. N.A. 43.9 N.A. 37.9 N.A. 63.5 N.A. 37.3 N.A.
P-Site Identity: 100 N.A. N.A. 100 N.A. 100 13.3 N.A. N.A. 6.6 N.A. 13.3 N.A. 0 N.A. 0 N.A.
P-Site Similarity: 100 N.A. N.A. 100 N.A. 100 26.6 N.A. N.A. 20 N.A. 20 N.A. 26.6 N.A. 26.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 27.8 22.9 N.A.
Protein Similarity: N.A. N.A. N.A. 43.2 33.9 N.A.
P-Site Identity: N.A. N.A. N.A. 0 20 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 10 0 10 10 0 30 0 0 0 10 10 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 0 0 10 0 0 % C
% Asp: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 0 0 0 10 10 0 0 0 10 0 10 0 10 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 10 0 10 0 10 10 10 0 0 0 0 10 10 10 0 % G
% His: 0 0 0 10 10 0 20 10 0 0 0 0 0 30 10 % H
% Ile: 10 0 0 20 0 0 10 0 0 0 0 0 0 0 0 % I
% Lys: 0 10 0 0 0 0 0 0 0 0 0 10 0 0 0 % K
% Leu: 40 0 0 10 0 40 0 10 0 0 30 10 10 10 0 % L
% Met: 0 10 0 0 0 0 0 0 0 10 0 0 0 10 0 % M
% Asn: 0 0 0 0 0 0 0 10 0 0 10 0 10 0 10 % N
% Pro: 0 10 0 10 30 10 0 10 40 0 0 0 30 10 30 % P
% Gln: 0 0 10 0 0 0 0 0 10 20 10 20 0 10 0 % Q
% Arg: 10 10 0 0 20 0 0 0 20 40 0 0 0 0 0 % R
% Ser: 10 30 40 30 20 0 40 40 20 0 0 20 0 10 10 % S
% Thr: 0 10 40 10 0 0 0 0 0 0 0 30 0 0 20 % T
% Val: 10 0 0 0 0 20 0 10 0 0 40 0 0 0 0 % V
% Trp: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 10 0 0 0 20 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _