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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD3
All Species:
27.27
Human Site:
S181
Identified Species:
60
UniProt:
Q86TU7
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q86TU7
NP_115609.2
594
67257
S181
P
Y
I
Q
T
L
P
S
E
Y
D
T
P
L
Y
Chimpanzee
Pan troglodytes
XP_522946
594
67230
S181
P
Y
I
Q
T
L
P
S
E
Y
D
T
P
L
Y
Rhesus Macaque
Macaca mulatta
XP_001103370
595
67455
S181
P
Y
I
Q
T
L
P
S
E
Y
D
T
P
L
Y
Dog
Lupus familis
XP_547974
589
66391
S181
P
Y
I
Q
T
L
P
S
E
Y
D
T
P
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q91WC0
594
67158
S181
P
Y
I
Q
T
L
P
S
E
Y
D
T
P
L
Y
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512656
355
39998
Chicken
Gallus gallus
Q5ZML9
593
67177
S181
P
Y
I
Q
T
L
P
S
E
Y
D
T
P
L
Y
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956348
596
67232
S181
P
Y
I
K
T
L
P
S
E
Y
D
T
P
L
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393639
457
52653
M70
K
V
K
R
L
E
E
M
K
T
E
S
S
K
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_798530
682
75899
P181
K
P
Y
L
D
V
L
P
S
S
Y
S
L
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XI84
482
54593
K96
E
V
V
L
E
I
P
K
R
L
W
I
N
P
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
98.6
90
N.A.
91.4
N.A.
N.A.
49.4
85.3
N.A.
70.6
N.A.
N.A.
32.4
N.A.
36.2
Protein Similarity:
100
99.8
99.5
94.7
N.A.
94.4
N.A.
N.A.
53.7
92.5
N.A.
84.7
N.A.
N.A.
47.6
N.A.
56.8
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
0
100
N.A.
93.3
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
0
100
N.A.
100
N.A.
N.A.
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
0
64
0
0
0
0
% D
% Glu:
10
0
0
0
10
10
10
0
64
0
10
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
64
0
0
10
0
0
0
0
0
10
0
0
0
% I
% Lys:
19
0
10
10
0
0
0
10
10
0
0
0
0
10
0
% K
% Leu:
0
0
0
19
10
64
10
0
0
10
0
0
10
64
10
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% N
% Pro:
64
10
0
0
0
0
73
10
0
0
0
0
64
19
0
% P
% Gln:
0
0
0
55
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
10
% R
% Ser:
0
0
0
0
0
0
0
64
10
10
0
19
10
0
0
% S
% Thr:
0
0
0
0
64
0
0
0
0
10
0
64
0
0
0
% T
% Val:
0
19
10
0
0
10
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% W
% Tyr:
0
64
10
0
0
0
0
0
0
64
10
0
0
0
64
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _