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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PXK
All Species:
24.55
Human Site:
S452
Identified Species:
45
UniProt:
Q7Z7A4
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z7A4
NP_060241.2
578
64950
S452
R
A
Q
S
H
H
G
S
E
E
E
R
K
K
R
Chimpanzee
Pan troglodytes
XP_001174144
580
65126
S452
R
A
Q
S
H
H
G
S
E
E
E
R
K
K
R
Rhesus Macaque
Macaca mulatta
XP_001094947
468
53990
M348
F
G
H
L
L
Y
E
M
T
Y
G
R
P
P
D
Dog
Lupus familis
XP_533779
498
56612
L378
S
R
L
L
Q
M
P
L
F
S
D
V
L
L
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8BX57
582
65213
S452
R
A
Q
S
H
H
G
S
E
E
E
R
K
R
R
Rat
Rattus norvegicus
Q4FZZ1
580
65080
S452
R
A
Q
S
H
H
G
S
E
E
E
R
K
R
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506344
166
19503
T46
N
N
Y
S
S
N
Y
T
E
I
A
L
Q
Q
V
Chicken
Gallus gallus
XP_414403
564
63568
S440
R
A
Q
S
H
H
G
S
E
E
E
K
K
K
R
Frog
Xenopus laevis
NP_001090231
577
64854
S452
R
A
Q
S
H
H
G
S
E
E
E
K
K
K
R
Zebra Danio
Brachydanio rerio
NP_001076277
575
64593
H454
L
T
R
A
Q
S
H
H
G
S
E
E
E
K
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610341
646
71703
H513
K
Q
K
A
K
L
E
H
K
Q
S
K
L
K
Q
Honey Bee
Apis mellifera
XP_392133
583
66076
K449
R
H
Q
K
R
L
V
K
V
Q
E
M
M
S
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783313
710
79220
K590
S
S
F
R
R
L
S
K
A
Q
A
H
H
N
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
76.9
84.5
N.A.
92.2
92.4
N.A.
25.9
83.3
80.6
73.3
N.A.
35.9
42.8
N.A.
35.7
Protein Similarity:
100
99.6
78.5
85.2
N.A.
95.5
95.6
N.A.
27.6
90.4
89.6
85.4
N.A.
54
61
N.A.
50.8
P-Site Identity:
100
100
6.6
0
N.A.
93.3
93.3
N.A.
13.3
93.3
93.3
20
N.A.
6.6
20
N.A.
0
P-Site Similarity:
100
100
13.3
6.6
N.A.
100
100
N.A.
40
100
100
40
N.A.
53.3
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
47
0
16
0
0
0
0
8
0
16
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
8
% D
% Glu:
0
0
0
0
0
0
16
0
54
47
62
8
8
0
0
% E
% Phe:
8
0
8
0
0
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
47
0
8
0
8
0
0
0
0
% G
% His:
0
8
8
0
47
47
8
16
0
0
0
8
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% I
% Lys:
8
0
8
8
8
0
0
16
8
0
0
24
47
47
0
% K
% Leu:
8
0
8
16
8
24
0
8
0
0
0
8
16
8
0
% L
% Met:
0
0
0
0
0
8
0
8
0
0
0
8
8
0
0
% M
% Asn:
8
8
0
0
0
8
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
8
8
0
% P
% Gln:
0
8
54
0
16
0
0
0
0
24
0
0
8
8
8
% Q
% Arg:
54
8
8
8
16
0
0
0
0
0
0
39
0
16
54
% R
% Ser:
16
8
0
54
8
8
8
47
0
16
8
0
0
8
16
% S
% Thr:
0
8
0
0
0
0
0
8
8
0
0
0
0
0
8
% T
% Val:
0
0
0
0
0
0
8
0
8
0
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
8
8
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _