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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC7
All Species:
14.85
Human Site:
S127
Identified Species:
36.3
UniProt:
Q7Z402
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7Z402
NP_079123.3
723
83502
S127
W
K
R
Y
S
S
K
S
W
K
R
F
L
E
K
Chimpanzee
Pan troglodytes
XP_510854
723
83614
S127
W
K
R
Y
S
S
K
S
W
K
R
F
L
E
K
Rhesus Macaque
Macaca mulatta
XP_001083257
723
83551
S127
W
K
R
Y
S
S
K
S
W
K
R
F
L
E
K
Dog
Lupus familis
XP_547110
882
101345
S245
W
K
R
Y
S
S
K
S
W
K
R
F
I
G
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8C428
726
83318
A133
W
K
R
F
L
E
K
A
R
E
M
T
T
H
L
Rat
Rattus norvegicus
Q496Z4
698
78193
T127
K
M
K
E
G
F
Q
T
I
Q
P
W
A
W
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509221
768
89299
H127
E
A
K
E
L
S
S
H
L
E
L
W
R
N
D
Chicken
Gallus gallus
Q5YCC5
735
84359
K127
K
S
W
K
K
A
L
K
D
I
K
E
L
S
S
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001921182
684
79088
L127
G
R
A
V
S
G
L
L
P
W
R
H
M
I
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395471
756
87723
A146
L
K
W
Q
R
R
K
A
W
Q
Q
F
R
I
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
97.7
75.1
N.A.
90.5
34.5
N.A.
64.1
57.9
N.A.
32.2
N.A.
N.A.
32.4
N.A.
N.A.
Protein Similarity:
100
99.4
98.3
78.5
N.A.
94.9
55.4
N.A.
77.9
73.6
N.A.
53.1
N.A.
N.A.
54.5
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
26.6
0
N.A.
6.6
6.6
N.A.
13.3
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
46.6
33.3
N.A.
26.6
20
N.A.
26.6
N.A.
N.A.
53.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
0
0
10
0
20
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
10
0
0
0
0
0
10
% D
% Glu:
10
0
0
20
0
10
0
0
0
20
0
10
0
30
0
% E
% Phe:
0
0
0
10
0
10
0
0
0
0
0
50
0
0
0
% F
% Gly:
10
0
0
0
10
10
0
0
0
0
0
0
0
10
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
0
10
0
10
10
% H
% Ile:
0
0
0
0
0
0
0
0
10
10
0
0
10
20
0
% I
% Lys:
20
60
20
10
10
0
60
10
0
40
10
0
0
0
40
% K
% Leu:
10
0
0
0
20
0
20
10
10
0
10
0
40
0
10
% L
% Met:
0
10
0
0
0
0
0
0
0
0
10
0
10
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% P
% Gln:
0
0
0
10
0
0
10
0
0
20
10
0
0
0
0
% Q
% Arg:
0
10
50
0
10
10
0
0
10
0
50
0
20
0
10
% R
% Ser:
0
10
0
0
50
50
10
40
0
0
0
0
0
10
10
% S
% Thr:
0
0
0
0
0
0
0
10
0
0
0
10
10
0
10
% T
% Val:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
50
0
20
0
0
0
0
0
50
10
0
20
0
10
0
% W
% Tyr:
0
0
0
40
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _