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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LRRC8D
All Species:
26.67
Human Site:
T251
Identified Species:
65.19
UniProt:
Q7L1W4
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7L1W4
NP_001127951.1
858
98201
T251
E
G
S
P
S
A
S
T
P
M
I
N
K
T
G
Chimpanzee
Pan troglodytes
XP_001150728
858
98142
T251
E
G
S
P
S
A
S
T
P
M
I
N
K
T
G
Rhesus Macaque
Macaca mulatta
XP_001087650
803
92361
R249
F
E
K
V
K
K
F
R
L
H
V
E
E
G
D
Dog
Lupus familis
XP_547288
858
98101
T251
E
G
S
P
S
A
S
T
P
M
I
N
K
T
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8BGR2
859
98095
T252
E
G
S
P
S
A
S
T
P
M
I
N
K
T
G
Rat
Rattus norvegicus
Q5U308
858
97921
T251
E
G
S
P
S
A
S
T
P
M
I
N
K
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507081
857
97379
T250
E
G
S
P
S
S
S
T
P
M
I
G
K
S
G
Chicken
Gallus gallus
XP_422352
856
97770
T249
E
G
S
P
S
A
S
T
P
M
I
T
K
S
G
Frog
Xenopus laevis
Q6NU09
806
92226
K249
K
A
L
F
E
K
V
K
K
F
R
H
H
V
E
Zebra Danio
Brachydanio rerio
Q7SXW3
601
67297
D59
S
V
W
R
L
N
L
D
T
P
Q
E
A
K
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
50.1
97.1
N.A.
95.9
96
N.A.
90.2
88.5
50.5
20.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
68.6
98.8
N.A.
98.2
98
N.A.
94.6
93.5
66.9
36.7
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
100
N.A.
100
100
N.A.
80
86.6
0
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
13.3
100
N.A.
100
100
N.A.
93.3
93.3
13.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
60
0
0
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
10
% D
% Glu:
70
10
0
0
10
0
0
0
0
0
0
20
10
0
10
% E
% Phe:
10
0
0
10
0
0
10
0
0
10
0
0
0
0
0
% F
% Gly:
0
70
0
0
0
0
0
0
0
0
0
10
0
10
70
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
10
10
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
70
0
0
0
0
% I
% Lys:
10
0
10
0
10
20
0
10
10
0
0
0
70
10
0
% K
% Leu:
0
0
10
0
10
0
10
0
10
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
70
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
10
0
0
0
0
0
50
0
0
0
% N
% Pro:
0
0
0
70
0
0
0
0
70
10
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
10
% Q
% Arg:
0
0
0
10
0
0
0
10
0
0
10
0
0
0
0
% R
% Ser:
10
0
70
0
70
10
70
0
0
0
0
0
0
20
0
% S
% Thr:
0
0
0
0
0
0
0
70
10
0
0
10
0
50
0
% T
% Val:
0
10
0
10
0
0
10
0
0
0
10
0
0
10
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _