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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MARK2
All Species:
9.7
Human Site:
Y323
Identified Species:
17.78
UniProt:
Q7KZI7
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q7KZI7
NP_001034558.2
788
87911
Y323
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
Chimpanzee
Pan troglodytes
XP_001172839
796
89049
F330
Y
T
E
P
D
P
D
F
N
D
T
K
R
I
D
Rhesus Macaque
Macaca mulatta
XP_001115591
788
87964
Y323
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
E
Dog
Lupus familis
XP_540890
798
88683
D342
P
Y
V
E
P
L
P
D
Y
K
D
P
R
R
T
Cat
Felis silvestris
Mouse
Mus musculus
Q05512
776
86287
L320
L
K
P
Y
V
E
P
L
P
D
Y
K
D
P
R
Rat
Rattus norvegicus
O08679
722
80853
P270
L
R
G
K
Y
R
I
P
F
Y
M
S
T
D
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511751
793
88836
F329
Y
L
E
P
E
P
D
F
N
D
T
K
R
I
D
Chicken
Gallus gallus
Q9IA88
798
88848
S324
D
R
Q
R
T
V
E
S
L
Q
N
S
S
Y
N
Frog
Xenopus laevis
NP_001080425
785
87931
Y327
Y
V
E
P
I
P
D
Y
K
D
P
K
R
T
E
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
E418
Q
V
Q
L
I
N
P
E
N
Q
I
V
E
T
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
Q440
F
I
E
P
P
K
D
Q
I
D
E
Q
R
I
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
M59
N
R
R
K
I
K
N
M
E
M
E
E
K
V
R
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
E181
V
H
R
D
L
K
P
E
N
L
L
L
D
E
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
68.2
99.7
95.1
N.A.
96.6
89.9
N.A.
68.4
30.3
84.3
27.5
N.A.
N.A.
N.A.
38.8
N.A.
Protein Similarity:
100
80.4
99.7
96.2
N.A.
97.7
90.9
N.A.
80.5
48.7
91.7
42.7
N.A.
N.A.
N.A.
49.9
N.A.
P-Site Identity:
100
46.6
100
6.6
N.A.
6.6
0
N.A.
46.6
0
86.6
13.3
N.A.
N.A.
N.A.
40
N.A.
P-Site Similarity:
100
66.6
100
6.6
N.A.
20
0
N.A.
73.3
13.3
100
33.3
N.A.
N.A.
N.A.
60
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
26.5
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.1
45.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
8
0
0
8
8
0
47
8
0
54
8
0
16
8
24
% D
% Glu:
0
0
47
8
8
8
8
16
8
0
16
8
8
8
31
% E
% Phe:
8
0
0
0
0
0
0
16
8
0
0
0
0
0
0
% F
% Gly:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
8
0
0
24
0
8
0
8
0
8
0
0
24
0
% I
% Lys:
0
8
0
16
0
24
0
0
24
8
0
31
8
0
0
% K
% Leu:
16
8
0
8
24
8
0
8
8
8
8
8
0
0
0
% L
% Met:
0
0
0
0
0
0
0
8
0
8
8
0
0
0
0
% M
% Asn:
8
0
0
0
0
8
8
0
31
0
8
0
0
0
8
% N
% Pro:
8
0
8
47
16
39
31
8
8
0
24
8
0
8
0
% P
% Gln:
8
0
16
0
0
0
0
8
0
16
0
8
0
0
0
% Q
% Arg:
0
24
16
8
0
8
0
0
0
0
0
16
54
8
16
% R
% Ser:
0
0
0
0
0
0
0
8
0
0
0
16
8
0
0
% S
% Thr:
0
8
0
0
8
0
0
0
0
0
16
0
8
31
8
% T
% Val:
8
31
8
0
8
8
0
0
0
0
0
8
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
39
8
0
8
8
0
0
24
8
8
8
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _