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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HECW1
All Species:
17.88
Human Site:
S1221
Identified Species:
32.78
UniProt:
Q76N89
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q76N89
NP_055867.3
1606
179554
S1221
R
A
S
A
R
A
P
S
P
Y
R
R
D
F
E
Chimpanzee
Pan troglodytes
XP_516001
1572
175733
A1187
R
A
N
A
R
A
P
A
P
Y
K
R
D
F
E
Rhesus Macaque
Macaca mulatta
XP_001096775
1606
179529
S1221
R
A
S
A
R
A
P
S
P
Y
R
R
D
F
E
Dog
Lupus familis
XP_850781
1366
151109
L1012
Q
G
P
G
K
I
K
L
I
I
R
R
D
H
L
Cat
Felis silvestris
Mouse
Mus musculus
Q8K4P8
1604
179451
S1219
R
A
S
A
R
A
P
S
P
Y
R
R
D
F
E
Rat
Rattus norvegicus
Q62940
887
102376
L533
P
N
K
F
E
M
K
L
R
R
A
N
I
L
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507682
1657
184662
S1272
R
A
S
V
R
A
P
S
P
Y
R
R
D
F
E
Chicken
Gallus gallus
XP_418870
1586
179204
S1201
R
A
S
A
R
A
P
S
P
Y
R
R
D
F
E
Frog
Xenopus laevis
Q2TAS2
751
86306
R397
Q
P
Q
A
G
H
C
R
I
E
V
S
R
E
E
Zebra Danio
Brachydanio rerio
A9JRZ0
765
87445
R411
Q
P
Q
A
G
H
C
R
I
E
V
S
R
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VVI3
1007
114856
R653
V
P
N
K
F
E
I
R
I
R
R
T
S
I
L
Honey Bee
Apis mellifera
XP_392900
1204
136801
L849
Q
G
P
G
K
L
K
L
H
I
R
R
E
H
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P39940
809
91798
C455
L
R
I
L
P
G
Q
C
H
I
K
V
R
R
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
56
99.1
75.2
N.A.
88.2
24.9
N.A.
82.1
80.3
23.1
23.4
N.A.
25.1
39
N.A.
N.A.
Protein Similarity:
100
67.8
99.6
78.6
N.A.
92.2
37.8
N.A.
86.9
86.8
33.2
33.6
N.A.
39.4
52.4
N.A.
N.A.
P-Site Identity:
100
80
100
20
N.A.
100
6.6
N.A.
93.3
100
13.3
13.3
N.A.
6.6
13.3
N.A.
N.A.
P-Site Similarity:
100
100
100
33.3
N.A.
100
6.6
N.A.
93.3
100
20
20
N.A.
13.3
33.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
25.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
36.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
47
0
54
0
47
0
8
0
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
16
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
54
0
0
% D
% Glu:
0
0
0
0
8
8
0
0
0
16
0
0
8
16
70
% E
% Phe:
0
0
0
8
8
0
0
0
0
0
0
0
0
47
8
% F
% Gly:
0
16
0
16
16
8
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
16
0
0
16
0
0
0
0
16
0
% H
% Ile:
0
0
8
0
0
8
8
0
31
24
0
0
8
8
0
% I
% Lys:
0
0
8
8
16
0
24
0
0
0
16
0
0
0
8
% K
% Leu:
8
0
0
8
0
8
0
24
0
0
0
0
0
8
16
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
16
0
0
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
8
24
16
0
8
0
47
0
47
0
0
0
0
0
0
% P
% Gln:
31
0
16
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
47
8
0
0
47
0
0
24
8
16
62
62
24
8
0
% R
% Ser:
0
0
39
0
0
0
0
39
0
0
0
16
8
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
8
0
0
8
0
0
0
0
0
0
16
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
47
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _