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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMTC3 All Species: 24.55
Human Site: Y490 Identified Species: 60
UniProt: Q6ZXV5 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6ZXV5 NP_861448.2 915 104009 Y490 H M N V G R T Y K N L N R T K
Chimpanzee Pan troglodytes XP_522486 914 103832 Y490 H M N V G R T Y K N L N R T K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_532644 915 103928 Y490 H M N V G R T Y K N L N R T K
Cat Felis silvestris
Mouse Mus musculus Q8BRH0 920 104179 Y495 H M N V G R T Y K N L N R S R
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q6DCD5 836 94386 I488 E M L Y R S G I K V N P A K A
Zebra Danio Brachydanio rerio XP_001922486 906 102514 Y490 H M N V G R T Y K N L N R S R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7K4B6 926 105342 F558 H I N V G R T F N N L K R Y A
Honey Bee Apis mellifera XP_393964 996 112258 Y491 H I N V G R T Y N H L K M F K
Nematode Worm Caenorhab. elegans Q20144 690 77719 A351 G I I S F L P A S N I F F T V
Sea Urchin Strong. purpuratus XP_797370 844 95271 Y497 W I N V G R T Y R Q L G K P A
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 N.A. 93.8 N.A. 89.7 N.A. N.A. N.A. N.A. 26 73 N.A. 51.2 47.9 28.2 47.3
Protein Similarity: 100 99.7 N.A. 97.1 N.A. 94.6 N.A. N.A. N.A. N.A. 43.2 85.9 N.A. 66.7 63.9 45.2 65.6
P-Site Identity: 100 100 N.A. 100 N.A. 86.6 N.A. N.A. N.A. N.A. 13.3 86.6 N.A. 60 60 13.3 46.6
P-Site Similarity: 100 100 N.A. 100 N.A. 100 N.A. N.A. N.A. N.A. 13.3 100 N.A. 73.3 73.3 26.6 66.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 10 0 0 0 0 10 0 30 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 10 0 0 10 0 0 0 10 10 10 0 % F
% Gly: 10 0 0 0 80 0 10 0 0 0 0 10 0 0 0 % G
% His: 70 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % H
% Ile: 0 40 10 0 0 0 0 10 0 0 10 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 60 0 0 20 10 10 40 % K
% Leu: 0 0 10 0 0 10 0 0 0 0 80 0 0 0 0 % L
% Met: 0 60 0 0 0 0 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 80 0 0 0 0 0 20 70 10 50 0 0 0 % N
% Pro: 0 0 0 0 0 0 10 0 0 0 0 10 0 10 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 80 0 0 10 0 0 0 60 0 20 % R
% Ser: 0 0 0 10 0 10 0 0 10 0 0 0 0 20 0 % S
% Thr: 0 0 0 0 0 0 80 0 0 0 0 0 0 40 0 % T
% Val: 0 0 0 80 0 0 0 0 0 10 0 0 0 0 10 % V
% Trp: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 10 0 0 0 70 0 0 0 0 0 10 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _