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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMTC3
All Species:
12.12
Human Site:
S660
Identified Species:
29.63
UniProt:
Q6ZXV5
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZXV5
NP_861448.2
915
104009
S660
E
A
R
K
R
L
L
S
Y
I
N
E
E
P
L
Chimpanzee
Pan troglodytes
XP_522486
914
103832
S659
E
A
R
K
R
L
L
S
Y
I
N
E
E
P
L
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_532644
915
103928
S659
E
A
R
K
R
L
L
S
Y
I
N
E
E
P
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8BRH0
920
104179
N664
E
A
R
K
R
L
L
N
Y
V
N
E
E
P
Q
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6DCD5
836
94386
Q634
I
V
Y
K
E
A
I
Q
K
M
P
R
Q
F
S
Zebra Danio
Brachydanio rerio
XP_001922486
906
102514
T659
E
A
N
R
R
F
L
T
Y
V
K
E
E
P
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7K4B6
926
105342
K727
V
S
R
S
R
L
Y
K
V
L
E
N
D
D
Q
Honey Bee
Apis mellifera
XP_393964
996
112258
K660
V
A
R
E
R
L
L
K
L
L
R
K
D
S
N
Nematode Worm
Caenorhab. elegans
Q20144
690
77719
R496
L
A
R
A
V
T
L
R
P
S
F
A
V
A
W
Sea Urchin
Strong. purpuratus
XP_797370
844
95271
A645
K
M
A
L
Y
N
S
A
L
Y
I
Q
E
S
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
N.A.
93.8
N.A.
89.7
N.A.
N.A.
N.A.
N.A.
26
73
N.A.
51.2
47.9
28.2
47.3
Protein Similarity:
100
99.7
N.A.
97.1
N.A.
94.6
N.A.
N.A.
N.A.
N.A.
43.2
85.9
N.A.
66.7
63.9
45.2
65.6
P-Site Identity:
100
100
N.A.
93.3
N.A.
80
N.A.
N.A.
N.A.
N.A.
6.6
53.3
N.A.
20
33.3
20
6.6
P-Site Similarity:
100
100
N.A.
93.3
N.A.
93.3
N.A.
N.A.
N.A.
N.A.
26.6
73.3
N.A.
40
60
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
70
10
10
0
10
0
10
0
0
0
10
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
20
10
10
% D
% Glu:
50
0
0
10
10
0
0
0
0
0
10
50
60
0
0
% E
% Phe:
0
0
0
0
0
10
0
0
0
0
10
0
0
10
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
0
0
0
10
0
0
30
10
0
0
0
0
% I
% Lys:
10
0
0
50
0
0
0
20
10
0
10
10
0
0
0
% K
% Leu:
10
0
0
10
0
60
70
0
20
20
0
0
0
0
20
% L
% Met:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% M
% Asn:
0
0
10
0
0
10
0
10
0
0
40
10
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
10
0
10
0
0
50
0
% P
% Gln:
0
0
0
0
0
0
0
10
0
0
0
10
10
0
30
% Q
% Arg:
0
0
70
10
70
0
0
10
0
0
10
10
0
0
0
% R
% Ser:
0
10
0
10
0
0
10
30
0
10
0
0
0
20
10
% S
% Thr:
0
0
0
0
0
10
0
10
0
0
0
0
0
0
0
% T
% Val:
20
10
0
0
10
0
0
0
10
20
0
0
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% W
% Tyr:
0
0
10
0
10
0
10
0
50
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _