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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HFE2 All Species: 17.27
Human Site: T50 Identified Species: 42.22
UniProt: Q6ZVN8 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6ZVN8 NP_660320.3 426 45080 T50 N A E Y V S S T L S L R G G G
Chimpanzee Pan troglodytes XP_001154526 426 45053 T50 N A E Y V S S T L S L R G G G
Rhesus Macaque Macaca mulatta XP_001092987 427 45031 T50 N A E Y V S S T L S L R G G G
Dog Lupus familis XP_533038 469 47864 P54 S L R G G G S P G A L R G G G
Cat Felis silvestris
Mouse Mus musculus Q7TQ32 420 44829 L50 Y V S S T L S L R G G G S P D
Rat Rattus norvegicus Q8N7M5 422 45203 T50 N A E Y V S F T L S L R G G G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505927 523 57162 W92 V V K A R A G W M G M G R G A
Chicken Gallus gallus Q8JG54 432 47757 E52 G S H H L G A E E T P E F C T
Frog Xenopus laevis NP_001080552 397 44061 Y41 I L K C T A D Y L Q A T S N P
Zebra Danio Brachydanio rerio NP_001038746 410 44454 T52 N S D F V A A T L E S G V I G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.3 97.8 84.8 N.A. 87.3 86.6 N.A. 40.9 47.4 40.1 46 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 99.7 98.5 87.6 N.A. 89.9 89.6 N.A. 52.7 61.8 53.9 61.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 40 N.A. 6.6 93.3 N.A. 6.6 0 6.6 33.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 53.3 N.A. 6.6 93.3 N.A. 33.3 33.3 20 66.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 40 0 10 0 30 20 0 0 10 10 0 0 0 10 % A
% Cys: 0 0 0 10 0 0 0 0 0 0 0 0 0 10 0 % C
% Asp: 0 0 10 0 0 0 10 0 0 0 0 0 0 0 10 % D
% Glu: 0 0 40 0 0 0 0 10 10 10 0 10 0 0 0 % E
% Phe: 0 0 0 10 0 0 10 0 0 0 0 0 10 0 0 % F
% Gly: 10 0 0 10 10 20 10 0 10 20 10 30 50 60 60 % G
% His: 0 0 10 10 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 10 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 0 0 20 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 20 0 0 10 10 0 10 60 0 50 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 10 0 10 0 0 0 0 % M
% Asn: 50 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % N
% Pro: 0 0 0 0 0 0 0 10 0 0 10 0 0 10 10 % P
% Gln: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % Q
% Arg: 0 0 10 0 10 0 0 0 10 0 0 50 10 0 0 % R
% Ser: 10 20 10 10 0 40 50 0 0 40 10 0 20 0 0 % S
% Thr: 0 0 0 0 20 0 0 50 0 10 0 10 0 0 10 % T
% Val: 10 20 0 0 50 0 0 0 0 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % W
% Tyr: 10 0 0 40 0 0 0 10 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _