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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HFE2
All Species:
23.94
Human Site:
T342
Identified Species:
58.52
UniProt:
Q6ZVN8
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZVN8
NP_660320.3
426
45080
T342
R
G
A
I
T
I
D
T
A
R
R
L
C
K
E
Chimpanzee
Pan troglodytes
XP_001154526
426
45053
T342
R
G
A
I
T
I
D
T
A
R
R
L
C
K
E
Rhesus Macaque
Macaca mulatta
XP_001092987
427
45031
T343
P
G
A
I
T
I
D
T
A
R
R
L
C
K
E
Dog
Lupus familis
XP_533038
469
47864
T385
R
G
A
I
N
I
D
T
A
K
Q
L
C
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q7TQ32
420
44829
T335
R
G
A
I
A
I
D
T
A
R
R
L
C
K
E
Rat
Rattus norvegicus
Q8N7M5
422
45203
T338
R
G
A
I
A
I
D
T
A
R
R
L
C
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505927
523
57162
P413
H
A
A
E
S
R
G
P
R
R
P
G
S
G
L
Chicken
Gallus gallus
Q8JG54
432
47757
S339
P
E
A
F
T
Y
E
S
A
T
A
K
C
R
E
Frog
Xenopus laevis
NP_001080552
397
44061
L326
P
E
T
G
L
K
R
L
T
S
A
S
S
A
A
Zebra Danio
Brachydanio rerio
NP_001038746
410
44454
F339
F
P
G
R
D
V
Y
F
Q
A
C
L
F
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
97.8
84.8
N.A.
87.3
86.6
N.A.
40.9
47.4
40.1
46
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.7
98.5
87.6
N.A.
89.9
89.6
N.A.
52.7
61.8
53.9
61.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
80
N.A.
93.3
93.3
N.A.
13.3
33.3
0
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
20
53.3
0
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
80
0
20
0
0
0
70
10
20
0
0
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
10
0
70
0
0
% C
% Asp:
0
0
0
0
10
0
60
0
0
0
0
0
0
10
0
% D
% Glu:
0
20
0
10
0
0
10
0
0
0
0
0
0
0
70
% E
% Phe:
10
0
0
10
0
0
0
10
0
0
0
0
10
0
0
% F
% Gly:
0
60
10
10
0
0
10
0
0
0
0
10
0
10
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
60
0
60
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
10
0
0
0
10
0
10
0
60
0
% K
% Leu:
0
0
0
0
10
0
0
10
0
0
0
70
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
30
10
0
0
0
0
0
10
0
0
10
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
10
0
10
0
0
0
0
% Q
% Arg:
50
0
0
10
0
10
10
0
10
60
50
0
0
10
0
% R
% Ser:
0
0
0
0
10
0
0
10
0
10
0
10
20
0
0
% S
% Thr:
0
0
10
0
40
0
0
60
10
10
0
0
0
0
0
% T
% Val:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
10
10
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _