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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC5
All Species:
1.52
Human Site:
Y307
Identified Species:
3.7
UniProt:
Q6UXY8
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UXY8
NP_001098718.1
1006
114770
Y307
S
M
E
M
A
N
S
Y
G
H
S
L
P
G
A
Chimpanzee
Pan troglodytes
XP_001153396
949
108074
E298
E
D
Y
P
E
G
I
E
M
A
S
M
E
M
A
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_547109
928
106078
D277
P
S
L
R
H
R
G
D
G
S
L
G
I
V
G
Cat
Felis silvestris
Mouse
Mus musculus
Q32NZ6
967
111052
H307
L
L
C
A
H
D
W
H
T
S
V
Q
G
Q
K
Rat
Rattus norvegicus
Q5M7W4
965
110699
P307
A
R
D
W
N
T
S
P
Q
G
Q
K
L
I
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
P309
P
Q
C
V
D
S
K
P
N
N
L
P
F
T
G
Chicken
Gallus gallus
Q5YCC5
735
84359
A84
P
D
G
G
E
R
G
A
I
P
L
W
E
L
P
Frog
Xenopus laevis
NP_001085652
725
84100
T74
L
V
S
E
L
Q
T
T
S
G
T
N
R
S
R
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395471
756
87723
D104
A
A
V
S
M
L
P
D
L
S
E
N
L
S
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
T234
Q
I
S
G
T
I
D
T
R
R
R
V
R
E
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.3
N.A.
72.4
N.A.
73.2
73.4
N.A.
50.8
20.5
26.7
N.A.
N.A.
N.A.
21.4
N.A.
24
Protein Similarity:
100
92.8
N.A.
78.3
N.A.
80
80.9
N.A.
63.4
37
43
N.A.
N.A.
N.A.
37.9
N.A.
39.9
P-Site Identity:
100
13.3
N.A.
6.6
N.A.
0
13.3
N.A.
0
0
0
N.A.
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
20
N.A.
6.6
N.A.
20
26.6
N.A.
20
0
20
N.A.
N.A.
N.A.
6.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
10
0
10
10
0
0
10
0
10
0
0
0
0
30
% A
% Cys:
0
0
20
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
20
10
0
10
10
10
20
0
0
0
0
0
0
0
% D
% Glu:
10
0
10
10
20
0
0
10
0
0
10
0
20
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
10
20
0
10
20
0
20
20
0
10
10
10
20
% G
% His:
0
0
0
0
20
0
0
10
0
10
0
0
0
0
0
% H
% Ile:
0
10
0
0
0
10
10
0
10
0
0
0
10
10
0
% I
% Lys:
0
0
0
0
0
0
10
0
0
0
0
10
0
0
10
% K
% Leu:
20
10
10
0
10
10
0
0
10
0
30
10
20
10
0
% L
% Met:
0
10
0
10
10
0
0
0
10
0
0
10
0
10
0
% M
% Asn:
0
0
0
0
10
10
0
0
10
10
0
20
0
0
10
% N
% Pro:
30
0
0
10
0
0
10
20
0
10
0
10
10
0
10
% P
% Gln:
10
10
0
0
0
10
0
0
10
0
10
10
0
10
10
% Q
% Arg:
0
10
0
10
0
20
0
0
10
10
10
0
20
0
10
% R
% Ser:
10
10
20
10
0
10
20
0
10
30
20
0
0
20
0
% S
% Thr:
0
0
0
0
10
10
10
20
10
0
10
0
0
10
0
% T
% Val:
0
10
10
10
0
0
0
0
0
0
10
10
0
10
0
% V
% Trp:
0
0
0
10
0
0
10
0
0
0
0
10
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _