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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC5
All Species:
2.73
Human Site:
T257
Identified Species:
6.67
UniProt:
Q6UXY8
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UXY8
NP_001098718.1
1006
114770
T257
H
D
Y
G
S
S
E
T
P
K
M
T
R
G
V
Chimpanzee
Pan troglodytes
XP_001153396
949
108074
N248
P
D
Y
S
D
A
E
N
G
H
D
Y
G
S
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_547109
928
106078
R227
F
W
E
P
D
Y
P
R
A
E
N
S
P
N
F
Cat
Felis silvestris
Mouse
Mus musculus
Q32NZ6
967
111052
R257
G
P
F
G
M
L
G
R
R
N
E
D
Y
P
E
Rat
Rattus norvegicus
Q5M7W4
965
110699
G257
G
I
L
G
R
E
D
G
D
Y
P
E
G
I
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
W259
F
F
L
S
L
Q
L
W
Q
K
T
L
K
V
I
Chicken
Gallus gallus
Q5YCC5
735
84359
P34
E
E
S
H
A
A
A
P
A
G
F
L
Q
E
L
Frog
Xenopus laevis
NP_001085652
725
84100
Y24
G
A
M
L
S
E
Y
Y
N
R
T
M
R
R
R
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395471
756
87723
S54
H
I
A
T
L
L
P
S
K
K
S
R
V
A
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
S184
R
S
A
S
L
R
R
S
R
S
T
S
R
R
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.3
N.A.
72.4
N.A.
73.2
73.4
N.A.
50.8
20.5
26.7
N.A.
N.A.
N.A.
21.4
N.A.
24
Protein Similarity:
100
92.8
N.A.
78.3
N.A.
80
80.9
N.A.
63.4
37
43
N.A.
N.A.
N.A.
37.9
N.A.
39.9
P-Site Identity:
100
20
N.A.
0
N.A.
6.6
6.6
N.A.
6.6
0
13.3
N.A.
N.A.
N.A.
13.3
N.A.
6.6
P-Site Similarity:
100
26.6
N.A.
13.3
N.A.
13.3
13.3
N.A.
20
33.3
20
N.A.
N.A.
N.A.
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
20
0
10
20
10
0
20
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
20
0
0
20
0
10
0
10
0
10
10
0
0
0
% D
% Glu:
10
10
10
0
0
20
20
0
0
10
10
10
0
10
20
% E
% Phe:
20
10
10
0
0
0
0
0
0
0
10
0
0
0
10
% F
% Gly:
30
0
0
30
0
0
10
10
10
10
0
0
20
10
0
% G
% His:
20
0
0
10
0
0
0
0
0
10
0
0
0
0
0
% H
% Ile:
0
20
0
0
0
0
0
0
0
0
0
0
0
10
10
% I
% Lys:
0
0
0
0
0
0
0
0
10
30
0
0
10
0
0
% K
% Leu:
0
0
20
10
30
20
10
0
0
0
0
20
0
0
10
% L
% Met:
0
0
10
0
10
0
0
0
0
0
10
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
10
10
10
0
0
10
10
% N
% Pro:
10
10
0
10
0
0
20
10
10
0
10
0
10
10
0
% P
% Gln:
0
0
0
0
0
10
0
0
10
0
0
0
10
0
0
% Q
% Arg:
10
0
0
0
10
10
10
20
20
10
0
10
30
20
10
% R
% Ser:
0
10
10
30
20
10
0
20
0
10
10
20
0
10
10
% S
% Thr:
0
0
0
10
0
0
0
10
0
0
30
10
0
0
10
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
10
% V
% Trp:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% W
% Tyr:
0
0
20
0
0
10
10
10
0
10
0
10
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _