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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMC5
All Species:
1.52
Human Site:
S391
Identified Species:
3.7
UniProt:
Q6UXY8
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UXY8
NP_001098718.1
1006
114770
S391
K
I
V
D
K
E
K
S
K
Q
T
H
R
I
L
Chimpanzee
Pan troglodytes
XP_001153396
949
108074
R381
P
R
T
M
E
E
K
R
N
L
R
K
I
V
D
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_547109
928
106078
K360
M
T
S
R
D
R
I
K
A
I
R
N
Q
P
R
Cat
Felis silvestris
Mouse
Mus musculus
Q32NZ6
967
111052
W393
L
L
N
Y
I
T
L
W
Q
K
R
F
K
V
I
Rat
Rattus norvegicus
Q5M7W4
965
110699
W390
L
L
N
Y
I
S
L
W
Q
K
R
F
K
V
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509198
962
110947
A393
P
Y
S
Y
T
R
G
A
S
R
I
L
C
S
W
Chicken
Gallus gallus
Q5YCC5
735
84359
L167
F
L
R
F
L
V
L
L
N
F
L
M
F
I
L
Frog
Xenopus laevis
NP_001085652
725
84100
S157
Q
I
G
G
R
F
G
S
S
V
L
S
Y
F
V
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395471
756
87723
K187
V
A
Y
F
L
F
I
K
W
L
M
Y
L
N
V
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783735
885
99854
P317
W
L
L
L
L
N
I
P
V
F
L
L
T
F
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.3
N.A.
72.4
N.A.
73.2
73.4
N.A.
50.8
20.5
26.7
N.A.
N.A.
N.A.
21.4
N.A.
24
Protein Similarity:
100
92.8
N.A.
78.3
N.A.
80
80.9
N.A.
63.4
37
43
N.A.
N.A.
N.A.
37.9
N.A.
39.9
P-Site Identity:
100
13.3
N.A.
0
N.A.
0
0
N.A.
0
13.3
13.3
N.A.
N.A.
N.A.
0
N.A.
0
P-Site Similarity:
100
26.6
N.A.
13.3
N.A.
40
40
N.A.
13.3
20
33.3
N.A.
N.A.
N.A.
13.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
0
0
10
10
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
10
% D
% Glu:
0
0
0
0
10
20
0
0
0
0
0
0
0
0
0
% E
% Phe:
10
0
0
20
0
20
0
0
0
20
0
20
10
20
0
% F
% Gly:
0
0
10
10
0
0
20
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
20
0
0
20
0
30
0
0
10
10
0
10
20
20
% I
% Lys:
10
0
0
0
10
0
20
20
10
20
0
10
20
0
0
% K
% Leu:
20
40
10
10
30
0
30
10
0
20
30
20
10
0
20
% L
% Met:
10
0
0
10
0
0
0
0
0
0
10
10
0
0
0
% M
% Asn:
0
0
20
0
0
10
0
0
20
0
0
10
0
10
0
% N
% Pro:
20
0
0
0
0
0
0
10
0
0
0
0
0
10
0
% P
% Gln:
10
0
0
0
0
0
0
0
20
10
0
0
10
0
0
% Q
% Arg:
0
10
10
10
10
20
0
10
0
10
40
0
10
0
10
% R
% Ser:
0
0
20
0
0
10
0
20
20
0
0
10
0
10
0
% S
% Thr:
0
10
10
0
10
10
0
0
0
0
10
0
10
0
0
% T
% Val:
10
0
10
0
0
10
0
0
10
10
0
0
0
30
20
% V
% Trp:
10
0
0
0
0
0
0
20
10
0
0
0
0
0
10
% W
% Tyr:
0
10
10
30
0
0
0
0
0
0
0
10
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _