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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMC5 All Species: 0.91
Human Site: S244 Identified Species: 2.22
UniProt: Q6UXY8 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6UXY8 NP_001098718.1 1006 114770 S244 T W R E P D Y S D A E N G H D
Chimpanzee Pan troglodytes XP_001153396 949 108074 P235 A E D N Q N L P S T W R E P D
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_547109 928 106078 P214 Y P G A E N Q P N S P N F F W
Cat Felis silvestris
Mouse Mus musculus Q32NZ6 967 111052 V244 S S S K S L A V I R R G N G P
Rat Rattus norvegicus Q5M7W4 965 110699 R244 K T L G V I G R S R G S F G I
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509198 962 110947 K246 G L T F R R F K S T L S E F F
Chicken Gallus gallus Q5YCC5 735 84359 G21 V T E S R S R G E F F S P E E
Frog Xenopus laevis NP_001085652 725 84100 T11 L A N M P S R T I G R S Q G A
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_395471 756 87723 L41 E A D L Q Q A L Q R D P S H I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_783735 885 99854 R171 H H H S K S M R K R S R S R S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 92.3 N.A. 72.4 N.A. 73.2 73.4 N.A. 50.8 20.5 26.7 N.A. N.A. N.A. 21.4 N.A. 24
Protein Similarity: 100 92.8 N.A. 78.3 N.A. 80 80.9 N.A. 63.4 37 43 N.A. N.A. N.A. 37.9 N.A. 39.9
P-Site Identity: 100 6.6 N.A. 6.6 N.A. 0 0 N.A. 0 0 6.6 N.A. N.A. N.A. 6.6 N.A. 0
P-Site Similarity: 100 13.3 N.A. 26.6 N.A. 13.3 6.6 N.A. 13.3 20 20 N.A. N.A. N.A. 13.3 N.A. 0
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 20 0 10 0 0 20 0 0 10 0 0 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 20 0 0 10 0 0 10 0 10 0 0 0 20 % D
% Glu: 10 10 10 10 10 0 0 0 10 0 10 0 20 10 10 % E
% Phe: 0 0 0 10 0 0 10 0 0 10 10 0 20 20 10 % F
% Gly: 10 0 10 10 0 0 10 10 0 10 10 10 10 30 0 % G
% His: 10 10 10 0 0 0 0 0 0 0 0 0 0 20 0 % H
% Ile: 0 0 0 0 0 10 0 0 20 0 0 0 0 0 20 % I
% Lys: 10 0 0 10 10 0 0 10 10 0 0 0 0 0 0 % K
% Leu: 10 10 10 10 0 10 10 10 0 0 10 0 0 0 0 % L
% Met: 0 0 0 10 0 0 10 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 10 0 20 0 0 10 0 0 20 10 0 0 % N
% Pro: 0 10 0 0 20 0 0 20 0 0 10 10 10 10 10 % P
% Gln: 0 0 0 0 20 10 10 0 10 0 0 0 10 0 0 % Q
% Arg: 0 0 10 0 20 10 20 20 0 40 20 20 0 10 0 % R
% Ser: 10 10 10 20 10 30 0 10 30 10 10 40 20 0 10 % S
% Thr: 10 20 10 0 0 0 0 10 0 20 0 0 0 0 0 % T
% Val: 10 0 0 0 10 0 0 10 0 0 0 0 0 0 0 % V
% Trp: 0 10 0 0 0 0 0 0 0 0 10 0 0 0 10 % W
% Tyr: 10 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _