KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
1.52
Human Site:
Y734
Identified Species:
2.78
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
Y734
M
S
M
D
L
P
L
Y
A
W
L
S
R
A
R
Chimpanzee
Pan troglodytes
XP_510596
794
86649
V732
I
V
L
V
F
V
T
V
F
L
V
L
Q
L
R
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
Q717
M
S
M
D
L
P
P
Q
T
W
L
S
R
A
R
Dog
Lupus familis
XP_542201
757
83381
A737
R
I
L
Y
R
L
P
A
A
R
L
E
P
G
W
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
Q635
W
W
L
Y
S
H
P
Q
Q
P
V
T
E
G
Q
Rat
Rattus norvegicus
Q78EH2
678
75721
Q658
G
S
A
S
E
P
L
Q
G
L
S
P
L
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
I547
L
Y
I
I
Y
Q
L
I
C
L
M
A
E
A
P
Chicken
Gallus gallus
NP_990046
789
86613
Q730
I
T
V
F
L
V
L
Q
V
R
S
G
F
S
L
Frog
Xenopus laevis
P29119
783
86425
R726
I
F
L
F
L
Q
L
R
S
G
G
V
L
G
R
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
L737
F
V
G
V
F
G
L
L
Q
L
R
T
L
G
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
Y1036
A
V
A
G
G
I
V
Y
H
R
R
A
M
A
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
G889
V
S
L
I
A
A
C
G
I
C
A
C
K
K
C
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
N792
Q
K
F
P
N
D
A
N
A
E
S
A
S
N
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
6.6
80
13.3
N.A.
0
26.6
N.A.
13.3
13.3
20
6.6
N.A.
20
N.A.
6.6
N.A.
P-Site Similarity:
100
33.3
80
20
N.A.
26.6
26.6
N.A.
40
40
40
20
N.A.
33.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
16
0
8
8
8
8
24
0
8
24
0
39
8
% A
% Cys:
0
0
0
0
0
0
8
0
8
8
0
8
0
0
8
% C
% Asp:
0
0
0
16
0
8
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
8
0
8
16
0
0
% E
% Phe:
8
8
8
16
16
0
0
0
8
0
0
0
8
0
0
% F
% Gly:
8
0
8
8
8
8
0
8
8
8
8
8
0
31
0
% G
% His:
0
0
0
0
0
8
0
0
8
0
0
0
0
0
0
% H
% Ile:
24
8
8
16
0
8
0
8
8
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
0
0
0
0
0
0
8
8
8
% K
% Leu:
8
0
39
0
31
8
47
8
0
31
24
8
24
8
8
% L
% Met:
16
0
16
0
0
0
0
0
0
0
8
0
8
0
0
% M
% Asn:
0
0
0
0
8
0
0
8
0
0
0
0
0
8
0
% N
% Pro:
0
0
0
8
0
24
24
0
0
8
0
8
8
0
8
% P
% Gln:
8
0
0
0
0
16
0
31
16
0
0
0
8
0
16
% Q
% Arg:
8
0
0
0
8
0
0
8
0
24
16
0
16
0
39
% R
% Ser:
0
31
0
8
8
0
0
0
8
0
24
16
8
8
0
% S
% Thr:
0
8
0
0
0
0
8
0
8
0
0
16
0
0
0
% T
% Val:
8
24
8
16
0
16
8
8
8
0
16
8
0
0
0
% V
% Trp:
8
8
0
0
0
0
0
0
0
16
0
0
0
0
8
% W
% Tyr:
0
8
0
16
8
0
0
16
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _