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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
23.94
Human Site:
Y576
Identified Species:
43.89
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
Y576
Y
R
Y
T
L
L
L
Y
G
T
A
E
D
M
T
Chimpanzee
Pan troglodytes
XP_510596
794
86649
Y571
T
K
F
T
L
V
L
Y
G
T
A
P
E
G
L
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
Y559
Y
R
Y
T
L
L
L
Y
G
T
A
E
D
M
T
Dog
Lupus familis
XP_542201
757
83381
Y578
Y
R
Y
T
L
L
L
Y
G
T
A
E
D
M
T
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
G479
N
V
T
A
C
S
D
G
S
R
R
R
L
I
R
Rat
Rattus norvegicus
Q78EH2
678
75721
R502
L
S
L
S
Y
S
R
R
G
D
L
E
I
F
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
Y390
L
D
D
K
G
Y
F
Y
N
S
G
V
L
H
S
Chicken
Gallus gallus
NP_990046
789
86613
Y572
T
K
F
T
L
V
L
Y
G
T
A
T
D
P
P
Frog
Xenopus laevis
P29119
783
86425
Y569
T
Q
F
V
L
V
L
Y
G
T
A
S
E
G
L
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
Y571
T
Q
F
T
L
V
L
Y
G
T
A
S
S
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
T790
M
I
F
Y
G
T
E
T
P
A
Q
P
D
D
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
L623
F
H
D
W
T
L
L
L
Y
G
T
A
D
P
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
K589
D
F
H
S
W
R
L
K
L
F
G
E
S
I
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
46.6
100
100
N.A.
0
13.3
N.A.
6.6
53.3
40
46.6
N.A.
6.6
N.A.
20
N.A.
P-Site Similarity:
100
73.3
100
100
N.A.
6.6
20
N.A.
20
73.3
66.6
80
N.A.
13.3
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
0
0
8
54
8
0
0
8
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
16
0
0
0
8
0
0
8
0
0
47
8
8
% D
% Glu:
0
0
0
0
0
0
8
0
0
0
0
39
16
0
0
% E
% Phe:
8
8
39
0
0
0
8
0
0
8
0
0
0
8
0
% F
% Gly:
0
0
0
0
16
0
0
8
62
8
16
0
0
16
0
% G
% His:
0
8
8
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
8
16
0
% I
% Lys:
0
16
0
8
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
16
0
8
0
54
31
70
8
8
0
8
0
16
8
24
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
24
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
0
16
0
16
8
% P
% Gln:
0
16
0
0
0
0
0
0
0
0
8
0
0
0
0
% Q
% Arg:
0
24
0
0
0
8
8
8
0
8
8
8
0
0
8
% R
% Ser:
0
8
0
16
0
16
0
0
8
8
0
16
16
0
16
% S
% Thr:
31
0
8
47
8
8
0
8
0
54
8
8
0
0
24
% T
% Val:
0
8
0
8
0
31
0
0
0
0
0
8
0
0
8
% V
% Trp:
0
0
0
8
8
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
24
0
24
8
8
8
0
62
8
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _