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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
10.91
Human Site:
Y561
Identified Species:
20
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
Y561
L
G
L
E
N
K
G
Y
Y
F
N
T
G
T
L
Chimpanzee
Pan troglodytes
XP_510596
794
86649
E556
L
E
I
E
N
T
S
E
A
N
N
Y
G
T
L
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
Y544
L
G
L
E
N
K
G
Y
Y
F
N
T
G
M
L
Dog
Lupus familis
XP_542201
757
83381
Y563
L
G
L
E
N
K
G
Y
Y
F
N
T
G
T
L
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
L464
V
H
T
P
T
P
I
L
P
R
M
L
V
P
K
Rat
Rattus norvegicus
Q78EH2
678
75721
S487
S
R
R
R
L
I
R
S
L
E
H
V
Q
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
P375
T
H
F
W
D
E
R
P
Q
G
V
W
T
L
E
Chicken
Gallus gallus
NP_990046
789
86613
D557
L
E
I
E
N
T
S
D
A
N
N
Y
G
T
L
Frog
Xenopus laevis
P29119
783
86425
N554
L
E
I
E
N
V
S
N
N
N
N
Y
G
T
L
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
G556
L
E
I
K
N
V
A
G
T
S
D
Y
G
T
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
M775
I
H
N
E
G
R
Y
M
A
Q
I
T
Q
W
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
T608
L
M
V
E
S
V
T
T
N
P
A
A
T
G
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
T574
D
W
K
I
K
V
K
T
T
E
N
G
H
R
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
46.6
93.3
100
N.A.
0
0
N.A.
0
46.6
46.6
33.3
N.A.
13.3
N.A.
13.3
N.A.
P-Site Similarity:
100
53.3
93.3
100
N.A.
6.6
6.6
N.A.
13.3
53.3
53.3
53.3
N.A.
26.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
24
0
8
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
8
0
0
8
0
0
8
0
0
0
8
% D
% Glu:
0
31
0
62
0
8
0
8
0
16
0
0
0
0
8
% E
% Phe:
0
0
8
0
0
0
0
0
0
24
0
0
0
0
0
% F
% Gly:
0
24
0
0
8
0
24
8
0
8
0
8
54
8
0
% G
% His:
0
24
0
0
0
0
0
0
0
0
8
0
8
0
0
% H
% Ile:
8
0
31
8
0
8
8
0
0
0
8
0
0
0
8
% I
% Lys:
0
0
8
8
8
24
8
0
0
0
0
0
0
0
8
% K
% Leu:
62
0
24
0
8
0
0
8
8
0
0
8
0
8
54
% L
% Met:
0
8
0
0
0
0
0
8
0
0
8
0
0
8
0
% M
% Asn:
0
0
8
0
54
0
0
8
16
24
54
0
0
0
0
% N
% Pro:
0
0
0
8
0
8
0
8
8
8
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
0
0
0
8
8
0
0
16
0
8
% Q
% Arg:
0
8
8
8
0
8
16
0
0
8
0
0
0
8
0
% R
% Ser:
8
0
0
0
8
0
24
8
0
8
0
0
0
0
0
% S
% Thr:
8
0
8
0
8
16
8
16
16
0
0
31
16
47
8
% T
% Val:
8
0
8
0
0
31
0
0
0
0
8
8
8
8
0
% V
% Trp:
0
8
0
8
0
0
0
0
0
0
0
8
0
8
0
% W
% Tyr:
0
0
0
0
0
0
8
24
24
0
0
31
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _