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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
29.7
Human Site:
Y255
Identified Species:
54.44
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
Y255
Q
P
Q
H
I
H
I
Y
S
A
S
W
G
P
E
Chimpanzee
Pan troglodytes
XP_510596
794
86649
Y250
N
P
N
H
I
H
I
Y
S
A
S
W
G
P
E
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
E241
G
T
I
T
D
V
I
E
A
Q
S
L
S
L
Q
Dog
Lupus familis
XP_542201
757
83381
Y257
Q
P
Q
H
I
H
I
Y
S
A
S
W
G
P
E
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
H162
D
D
G
I
E
K
D
H
P
D
L
W
A
N
Y
Rat
Rattus norvegicus
Q78EH2
678
75721
Q185
N
D
Y
D
P
D
P
Q
P
R
Y
T
P
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
A73
L
V
E
A
Q
S
L
A
L
Q
P
Q
H
I
D
Chicken
Gallus gallus
NP_990046
789
86613
Y251
N
P
N
H
I
H
I
Y
S
A
S
W
G
P
E
Frog
Xenopus laevis
P29119
783
86425
Y248
N
P
N
H
I
H
I
Y
S
A
S
W
G
P
E
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
Y250
N
P
Q
H
I
D
I
Y
S
A
S
W
G
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
Y469
N
P
Q
H
I
D
I
Y
S
A
S
W
G
P
D
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
Y297
N
Q
D
H
I
D
I
Y
S
A
S
W
G
P
E
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
Y269
G
L
D
V
N
D
I
Y
S
C
S
W
G
P
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
86.6
13.3
100
N.A.
6.6
0
N.A.
0
86.6
86.6
86.6
N.A.
80
N.A.
73.3
N.A.
P-Site Similarity:
100
86.6
26.6
100
N.A.
13.3
6.6
N.A.
20
86.6
86.6
86.6
N.A.
86.6
N.A.
73.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
0
8
8
62
0
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% C
% Asp:
8
16
16
8
8
39
8
0
0
8
0
0
0
0
24
% D
% Glu:
0
0
8
0
8
0
0
8
0
0
0
0
0
0
54
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
16
0
8
0
0
0
0
0
0
0
0
0
70
0
0
% G
% His:
0
0
0
62
0
39
0
8
0
0
0
0
8
0
0
% H
% Ile:
0
0
8
8
62
0
77
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% K
% Leu:
8
8
0
0
0
0
8
0
8
0
8
8
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
54
0
24
0
8
0
0
0
0
0
0
0
0
16
0
% N
% Pro:
0
54
0
0
8
0
8
0
16
0
8
0
8
70
0
% P
% Gln:
16
8
31
0
8
0
0
8
0
16
0
8
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
0
70
0
77
0
8
0
0
% S
% Thr:
0
8
0
8
0
0
0
0
0
0
0
8
0
0
0
% T
% Val:
0
8
0
8
0
8
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
77
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
70
0
0
8
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _