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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
8.79
Human Site:
T743
Identified Species:
16.11
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
T743
W
L
S
R
A
R
A
T
P
T
K
P
Q
V
W
Chimpanzee
Pan troglodytes
XP_510596
794
86649
G741
L
V
L
Q
L
R
S
G
F
S
F
R
G
V
K
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
T726
W
L
S
R
A
R
A
T
P
T
K
P
Q
V
R
Dog
Lupus familis
XP_542201
757
83381
S746
R
L
E
P
G
W
G
S
E
N
L
P
R
G
G
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
S644
P
V
T
E
G
Q
A
S
C
H
P
P
V
T
P
Rat
Rattus norvegicus
Q78EH2
678
75721
L667
L
S
P
L
A
A
I
L
A
I
S
L
G
P
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
P556
L
M
A
E
A
P
G
P
A
E
E
P
N
F
A
Chicken
Gallus gallus
NP_990046
789
86613
G739
R
S
G
F
S
L
R
G
V
K
V
Y
A
L
D
Frog
Xenopus laevis
P29119
783
86425
R735
G
G
V
L
G
R
K
R
L
Y
M
L
D
S
G
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
K746
L
R
T
L
G
Q
K
K
Q
H
L
G
Q
E
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
N1045
R
R
A
M
A
R
S
N
E
L
Y
S
R
V
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
S898
C
A
C
K
K
C
A
S
E
T
K
S
S
N
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
Q801
E
S
A
S
N
K
L
Q
E
L
Q
P
D
V
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
13.3
93.3
13.3
N.A.
13.3
13.3
N.A.
13.3
0
6.6
6.6
N.A.
20
N.A.
20
N.A.
P-Site Similarity:
100
40
93.3
26.6
N.A.
40
13.3
N.A.
33.3
13.3
6.6
20
N.A.
40
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
24
0
39
8
31
0
16
0
0
0
8
0
8
% A
% Cys:
8
0
8
0
0
8
0
0
8
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
16
0
8
% D
% Glu:
8
0
8
16
0
0
0
0
31
8
8
0
0
8
8
% E
% Phe:
0
0
0
8
0
0
0
0
8
0
8
0
0
8
0
% F
% Gly:
8
8
8
0
31
0
16
16
0
0
0
8
16
8
16
% G
% His:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
8
0
0
0
0
0
% I
% Lys:
0
0
0
8
8
8
16
8
0
8
24
0
0
0
8
% K
% Leu:
31
24
8
24
8
8
8
8
8
16
16
16
0
8
0
% L
% Met:
0
8
0
8
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
8
0
8
0
0
8
8
0
% N
% Pro:
8
0
8
8
0
8
0
8
16
0
8
47
0
8
16
% P
% Gln:
0
0
0
8
0
16
0
8
8
0
8
0
24
0
0
% Q
% Arg:
24
16
0
16
0
39
8
8
0
0
0
8
16
0
8
% R
% Ser:
0
24
16
8
8
0
16
24
0
8
8
16
8
8
8
% S
% Thr:
0
0
16
0
0
0
0
16
0
24
0
0
0
8
0
% T
% Val:
0
16
8
0
0
0
0
0
8
0
8
0
8
39
8
% V
% Trp:
16
0
0
0
0
8
0
0
0
0
0
0
0
0
16
% W
% Tyr:
0
0
0
0
0
0
0
0
0
8
8
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _