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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
6.67
Human Site:
T641
Identified Species:
12.22
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
T641
V
T
A
G
P
G
H
T
A
A
P
A
L
R
V
Chimpanzee
Pan troglodytes
XP_510596
794
86649
I636
T
E
N
D
V
E
T
I
R
A
S
V
C
A
P
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
T624
V
T
A
R
P
G
H
T
A
A
L
A
L
R
V
Dog
Lupus familis
XP_542201
757
83381
R643
A
V
T
G
G
P
G
R
P
A
T
P
A
L
H
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
D544
F
M
S
T
H
Y
W
D
E
D
P
Q
G
L
W
Rat
Rattus norvegicus
Q78EH2
678
75721
L567
Y
Y
Y
N
T
G
T
L
Y
Y
C
T
L
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
P455
Y
C
P
P
H
Y
T
P
V
H
Q
G
L
S
S
Chicken
Gallus gallus
NP_990046
789
86613
E637
Y
N
L
E
N
S
M
E
P
I
A
P
Q
L
C
Frog
Xenopus laevis
P29119
783
86425
L634
L
D
N
N
I
E
P
L
L
V
N
V
C
V
P
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
E636
R
P
T
I
L
N
N
E
L
S
S
V
L
H
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
C855
L
K
W
S
D
R
K
C
L
E
C
N
D
S
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
S688
N
G
G
C
T
E
S
S
S
A
T
S
C
F
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
T654
T
S
A
I
P
Q
T
T
T
A
S
T
D
P
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
6.6
86.6
13.3
N.A.
6.6
13.3
N.A.
6.6
0
0
6.6
N.A.
0
N.A.
6.6
N.A.
P-Site Similarity:
100
6.6
86.6
13.3
N.A.
13.3
20
N.A.
6.6
0
6.6
20
N.A.
6.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
24
0
0
0
0
0
16
47
8
16
8
8
16
% A
% Cys:
0
8
0
8
0
0
0
8
0
0
16
0
24
0
8
% C
% Asp:
0
8
0
8
8
0
0
8
0
8
0
0
16
0
8
% D
% Glu:
0
8
0
8
0
24
0
16
8
8
0
0
0
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
8
8
16
8
24
8
0
0
0
0
8
8
0
0
% G
% His:
0
0
0
0
16
0
16
0
0
8
0
0
0
8
8
% H
% Ile:
0
0
0
16
8
0
0
8
0
8
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% K
% Leu:
16
0
8
0
8
0
0
16
24
0
8
0
39
31
8
% L
% Met:
0
8
0
0
0
0
8
0
0
0
0
0
0
0
0
% M
% Asn:
8
8
16
16
8
8
8
0
0
0
8
8
0
0
0
% N
% Pro:
0
8
8
8
24
8
8
8
16
0
16
16
0
8
24
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
8
8
8
0
0
% Q
% Arg:
8
0
0
8
0
8
0
8
8
0
0
0
0
16
0
% R
% Ser:
0
8
8
8
0
8
8
8
8
8
24
8
0
16
8
% S
% Thr:
16
16
16
8
16
0
31
24
8
0
16
16
0
0
0
% T
% Val:
16
8
0
0
8
0
0
0
8
8
0
24
0
8
16
% V
% Trp:
0
0
8
0
0
0
8
0
0
0
0
0
0
0
8
% W
% Tyr:
24
8
8
0
0
16
0
0
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _