KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
5.15
Human Site:
T449
Identified Species:
9.44
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
T449
T
A
R
T
W
L
P
T
Q
P
Q
R
K
C
A
Chimpanzee
Pan troglodytes
XP_510596
794
86649
V444
L
A
Q
N
W
T
T
V
A
P
Q
R
K
C
I
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
T432
S
P
A
G
R
P
P
T
P
Q
Q
A
A
G
G
Dog
Lupus familis
XP_542201
757
83381
T451
M
A
R
T
W
L
P
T
Q
P
Q
Q
K
C
V
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
Q352
S
G
V
V
T
D
P
Q
I
V
T
T
D
L
H
Rat
Rattus norvegicus
Q78EH2
678
75721
L375
G
T
S
A
S
A
P
L
A
A
G
M
I
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
A263
F
G
Y
G
L
L
D
A
G
V
L
V
Q
L
A
Chicken
Gallus gallus
NP_990046
789
86613
V445
L
A
R
N
W
I
T
V
G
P
Q
R
K
C
V
Frog
Xenopus laevis
P29119
783
86425
V442
M
A
K
T
W
V
T
V
G
P
Q
R
K
Y
V
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
V444
L
A
K
N
W
T
N
V
G
P
Q
H
K
C
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
V663
V
A
R
N
W
K
A
V
P
E
Q
Q
R
C
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
H496
W
K
T
V
P
E
Q
H
I
C
T
Y
E
Y
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
V462
M
S
K
T
W
E
N
V
N
A
Q
T
W
F
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
46.6
20
80
N.A.
6.6
6.6
N.A.
13.3
53.3
46.6
40
N.A.
33.3
N.A.
0
N.A.
P-Site Similarity:
100
53.3
26.6
86.6
N.A.
13.3
6.6
N.A.
20
60
60
46.6
N.A.
46.6
N.A.
6.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
54
8
8
0
8
8
8
16
16
0
8
8
8
16
% A
% Cys:
0
0
0
0
0
0
0
0
0
8
0
0
0
47
0
% C
% Asp:
0
0
0
0
0
8
8
0
0
0
0
0
8
0
0
% D
% Glu:
0
0
0
0
0
16
0
0
0
8
0
0
8
0
8
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
8
16
0
16
0
0
0
0
31
0
8
0
0
8
8
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
8
% H
% Ile:
0
0
0
0
0
8
0
0
16
0
0
0
8
0
8
% I
% Lys:
0
8
24
0
0
8
0
0
0
0
0
0
47
0
0
% K
% Leu:
24
0
0
0
8
24
0
8
0
0
8
0
0
16
8
% L
% Met:
24
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
31
0
0
16
0
8
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
8
8
39
0
16
47
0
0
0
0
0
% P
% Gln:
0
0
8
0
0
0
8
8
16
8
70
16
8
0
0
% Q
% Arg:
0
0
31
0
8
0
0
0
0
0
0
31
8
0
8
% R
% Ser:
16
8
8
0
8
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
8
8
8
31
8
16
24
24
0
0
16
16
0
0
0
% T
% Val:
8
0
8
16
0
8
0
47
0
16
0
8
0
0
31
% V
% Trp:
8
0
0
0
62
0
0
0
0
0
0
0
8
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
8
0
16
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _