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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
19.09
Human Site:
T418
Identified Species:
35
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
T418
L
Q
A
E
D
W
R
T
N
G
V
G
R
Q
V
Chimpanzee
Pan troglodytes
XP_510596
794
86649
T413
L
N
A
N
D
W
A
T
N
G
V
G
R
K
V
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
R401
F
E
N
A
N
P
G
R
A
Q
W
L
T
P
V
Dog
Lupus familis
XP_542201
757
83381
T420
L
Q
A
E
D
W
R
T
N
G
V
G
R
Q
V
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
S321
I
H
T
L
S
V
G
S
T
T
R
Q
G
R
V
Rat
Rattus norvegicus
Q78EH2
678
75721
S344
S
T
F
T
T
T
F
S
S
G
V
V
T
D
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
S232
M
H
H
L
V
V
R
S
S
S
P
A
H
L
Q
Chicken
Gallus gallus
NP_990046
789
86613
T414
L
N
A
N
D
W
V
T
N
G
V
G
R
K
V
Frog
Xenopus laevis
P29119
783
86425
T411
L
N
A
N
D
W
I
T
N
G
V
G
R
K
V
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
I413
L
T
T
N
D
W
K
I
N
G
V
G
R
R
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
R632
L
K
D
P
S
W
S
R
N
G
V
G
R
R
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
G465
G
W
S
R
N
G
V
G
R
M
V
S
N
K
F
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
D431
N
A
D
G
D
W
R
D
S
A
M
G
K
K
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
73.3
6.6
100
N.A.
6.6
13.3
N.A.
6.6
73.3
73.3
60
N.A.
53.3
N.A.
6.6
N.A.
P-Site Similarity:
100
80
20
100
N.A.
26.6
26.6
N.A.
26.6
80
80
73.3
N.A.
66.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
39
8
0
0
8
0
8
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
16
0
54
0
0
8
0
0
0
0
0
8
0
% D
% Glu:
0
8
0
16
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
0
8
0
0
0
8
0
0
0
0
0
0
0
8
% F
% Gly:
8
0
0
8
0
8
16
8
0
62
0
62
8
0
0
% G
% His:
0
16
8
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
8
0
0
0
0
0
8
8
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
0
0
8
0
0
0
0
0
8
39
0
% K
% Leu:
54
0
0
16
0
0
0
0
0
0
0
8
0
8
0
% L
% Met:
8
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% M
% Asn:
8
24
8
31
16
0
0
0
54
0
0
0
8
0
0
% N
% Pro:
0
0
0
8
0
8
0
0
0
0
8
0
0
8
8
% P
% Gln:
0
16
0
0
0
0
0
0
0
8
0
8
0
16
8
% Q
% Arg:
0
0
0
8
0
0
31
16
8
0
8
0
54
24
0
% R
% Ser:
8
0
8
0
16
0
8
24
24
8
0
8
0
0
0
% S
% Thr:
0
16
16
8
8
8
0
39
8
8
0
0
16
0
0
% T
% Val:
0
0
0
0
8
16
16
0
0
0
70
8
0
0
70
% V
% Trp:
0
8
0
0
0
62
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _