KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
8.18
Human Site:
S673
Identified Species:
15
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
S673
D
C
T
S
C
P
P
S
S
T
L
D
Q
Q
Q
Chimpanzee
Pan troglodytes
XP_510596
794
86649
L668
S
C
P
S
H
A
S
L
D
P
V
E
Q
T
C
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
S656
D
C
T
S
C
P
P
S
S
T
L
D
Q
Q
Q
Dog
Lupus familis
XP_542201
757
83381
P675
L
N
C
T
A
C
P
P
S
Y
S
L
R
E
H
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
G576
Y
Y
T
L
L
L
Y
G
T
A
E
D
M
T
A
Rat
Rattus norvegicus
Q78EH2
678
75721
A599
H
C
P
L
S
I
V
A
E
L
C
L
I
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
N487
S
C
Y
T
C
Q
S
N
L
T
N
N
C
T
T
Chicken
Gallus gallus
NP_990046
789
86613
S669
C
L
T
C
P
A
H
S
H
F
S
S
L
D
L
Frog
Xenopus laevis
P29119
783
86425
Y666
T
C
P
A
H
S
H
Y
N
L
L
D
Y
S
C
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
P668
Q
D
C
L
S
C
P
P
H
S
H
L
G
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
E887
L
D
K
F
Q
A
E
E
D
E
Q
D
D
E
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
T720
C
V
Q
K
C
D
D
T
Y
Y
L
D
G
D
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
I686
Y
F
L
T
I
F
L
I
G
A
T
F
L
V
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
20
100
13.3
N.A.
13.3
6.6
N.A.
20
13.3
20
6.6
N.A.
6.6
N.A.
20
N.A.
P-Site Similarity:
100
33.3
100
33.3
N.A.
20
13.3
N.A.
40
13.3
33.3
13.3
N.A.
13.3
N.A.
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
24
0
8
0
16
0
0
0
0
8
% A
% Cys:
16
47
16
8
31
16
0
0
0
0
8
0
8
0
16
% C
% Asp:
16
16
0
0
0
8
8
0
16
0
0
47
8
16
0
% D
% Glu:
0
0
0
0
0
0
8
8
8
8
8
8
0
16
0
% E
% Phe:
0
8
0
8
0
8
0
0
0
8
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
8
0
0
0
16
0
0
% G
% His:
8
0
0
0
16
0
16
0
16
0
8
0
0
0
8
% H
% Ile:
0
0
0
0
8
8
0
8
0
0
0
0
8
0
0
% I
% Lys:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
8
% K
% Leu:
16
8
8
24
8
8
8
8
8
16
31
24
16
0
24
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
0
0
0
0
0
8
8
0
8
8
0
0
0
% N
% Pro:
0
0
24
0
8
16
31
16
0
8
0
0
0
8
0
% P
% Gln:
8
0
8
0
8
8
0
0
0
0
8
0
24
16
16
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
16
0
0
24
16
8
16
24
24
8
16
8
0
16
8
% S
% Thr:
8
0
31
24
0
0
0
8
8
24
8
0
0
24
8
% T
% Val:
0
8
0
0
0
0
8
0
0
0
8
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
16
8
8
0
0
0
8
8
8
16
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _