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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PCSK4
All Species:
18.18
Human Site:
S488
Identified Species:
33.33
UniProt:
Q6UW60
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6UW60
NP_060043.2
755
82795
S488
G
L
H
N
S
I
R
S
L
E
H
V
Q
A
Q
Chimpanzee
Pan troglodytes
XP_510596
794
86649
R483
G
E
P
N
H
I
T
R
L
E
H
A
Q
A
R
Rhesus Macaque
Macaca mulatta
XP_001095657
745
81119
S471
G
R
H
N
S
I
R
S
L
E
H
V
Q
A
Q
Dog
Lupus familis
XP_542201
757
83381
S490
G
R
A
N
Y
I
R
S
L
E
H
V
Q
V
Q
Cat
Felis silvestris
Mouse
Mus musculus
P29121
655
73195
T391
L
E
A
N
P
L
L
T
W
R
D
L
Q
H
L
Rat
Rattus norvegicus
Q78EH2
678
75721
R414
Q
L
Q
A
E
D
W
R
I
N
G
V
G
R
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518057
567
61585
N302
S
T
L
H
I
S
K
N
I
S
A
C
A
G
G
Chicken
Gallus gallus
NP_990046
789
86613
R484
G
K
A
N
Y
I
S
R
L
E
H
A
Q
A
R
Frog
Xenopus laevis
P29119
783
86425
T481
G
M
S
N
Y
I
S
T
L
E
H
V
Q
A
R
Zebra Danio
Brachydanio rerio
NP_001038571
806
88169
S483
G
M
A
N
F
V
S
S
L
E
H
V
Q
A
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P30430
1101
120975
E702
C
R
S
V
N
Y
L
E
H
V
Q
A
K
I
T
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P51559
943
103128
Y535
E
S
G
T
P
V
L
Y
L
E
H
V
Q
V
H
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P13134
814
89984
N501
E
K
S
L
Q
D
A
N
F
K
R
I
E
H
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
51.7
83.7
81.3
N.A.
70.5
69.5
N.A.
45
54.2
51.7
50.7
N.A.
32.7
N.A.
36.6
N.A.
Protein Similarity:
100
64.2
86.3
86.7
N.A.
77.4
77.6
N.A.
54.2
65.6
64.6
63.9
N.A.
44.4
N.A.
49.4
N.A.
P-Site Identity:
100
53.3
93.3
73.3
N.A.
13.3
20
N.A.
0
53.3
60
66.6
N.A.
0
N.A.
33.3
N.A.
P-Site Similarity:
100
60
93.3
73.3
N.A.
33.3
26.6
N.A.
26.6
60
80
80
N.A.
13.3
N.A.
40
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
28.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
44.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
31
8
0
0
8
0
0
0
8
24
8
47
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
0
0
0
0
16
0
0
0
0
8
0
0
0
0
% D
% Glu:
16
16
0
0
8
0
0
8
0
62
0
0
8
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
8
0
0
0
0
0
0
% F
% Gly:
54
0
8
0
0
0
0
0
0
0
8
0
8
8
8
% G
% His:
0
0
16
8
8
0
0
0
8
0
62
0
0
16
8
% H
% Ile:
0
0
0
0
8
47
0
0
16
0
0
8
0
8
0
% I
% Lys:
0
16
0
0
0
0
8
0
0
8
0
0
8
0
0
% K
% Leu:
8
16
8
8
0
8
24
0
62
0
0
8
0
0
8
% L
% Met:
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
62
8
0
0
16
0
8
0
0
0
0
0
% N
% Pro:
0
0
8
0
16
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
8
0
8
0
0
0
0
0
8
0
70
0
39
% Q
% Arg:
0
24
0
0
0
0
24
24
0
8
8
0
0
8
24
% R
% Ser:
8
8
24
0
16
8
24
31
0
8
0
0
0
0
0
% S
% Thr:
0
8
0
8
0
0
8
16
0
0
0
0
0
0
8
% T
% Val:
0
0
0
8
0
16
0
0
0
8
0
54
0
16
8
% V
% Trp:
0
0
0
0
0
0
8
0
8
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
24
8
0
8
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _