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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EDC4
All Species:
13.03
Human Site:
T545
Identified Species:
28.67
UniProt:
Q6P2E9
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2E9
NP_055144.3
1401
151661
T545
H
T
A
H
E
D
F
T
F
G
E
S
R
P
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001089684
1300
138998
R490
D
F
T
F
G
E
S
R
P
E
L
G
S
E
G
Dog
Lupus familis
XP_546871
1484
160920
A630
H
T
T
H
E
D
F
A
F
G
E
S
R
P
E
Cat
Felis silvestris
Mouse
Mus musculus
Q3UJB9
1406
152465
T545
H
T
A
H
E
D
F
T
F
G
E
S
R
P
E
Rat
Rattus norvegicus
Q3ZAV8
1407
152577
T545
H
T
A
H
E
D
F
T
F
G
E
S
R
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_414022
1419
155974
A544
H
G
S
H
E
E
F
A
F
P
D
H
I
A
D
Frog
Xenopus laevis
Q7ZXT3
1391
153901
T532
A
E
P
A
I
L
G
T
A
Q
P
Q
Q
E
N
Zebra Danio
Brachydanio rerio
Q1LUT1
1384
151831
S539
S
G
S
Q
D
G
F
S
F
S
D
P
L
A
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKK1
1354
149232
K550
Y
Q
P
C
V
A
E
K
T
E
R
S
S
L
N
Honey Bee
Apis mellifera
XP_396550
1075
119372
S289
P
H
G
G
R
P
I
S
C
L
F
F
L
D
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784386
1287
142473
S490
K
Q
E
I
M
A
G
S
I
N
T
T
T
S
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.8
90.1
N.A.
94.8
94.4
N.A.
N.A.
74.3
62.4
61.6
N.A.
25.1
29.9
N.A.
32.9
Protein Similarity:
100
N.A.
70.2
91.5
N.A.
97
96.8
N.A.
N.A.
84.9
78.5
77.4
N.A.
45.4
48.1
N.A.
50.6
P-Site Identity:
100
N.A.
0
86.6
N.A.
100
100
N.A.
N.A.
33.3
6.6
13.3
N.A.
6.6
0
N.A.
0
P-Site Similarity:
100
N.A.
6.6
86.6
N.A.
100
100
N.A.
N.A.
60
13.3
46.6
N.A.
13.3
13.3
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
28
10
0
19
0
19
10
0
0
0
0
19
0
% A
% Cys:
0
0
0
10
0
0
0
0
10
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
10
37
0
0
0
0
19
0
0
10
28
% D
% Glu:
0
10
10
0
46
19
10
0
0
19
37
0
0
19
37
% E
% Phe:
0
10
0
10
0
0
55
0
55
0
10
10
0
0
0
% F
% Gly:
0
19
10
10
10
10
19
0
0
37
0
10
0
0
10
% G
% His:
46
10
0
46
0
0
0
0
0
0
0
10
0
0
10
% H
% Ile:
0
0
0
10
10
0
10
0
10
0
0
0
10
0
0
% I
% Lys:
10
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
10
0
0
0
10
10
0
19
10
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
19
% N
% Pro:
10
0
19
0
0
10
0
0
10
10
10
10
0
37
0
% P
% Gln:
0
19
0
10
0
0
0
0
0
10
0
10
10
0
0
% Q
% Arg:
0
0
0
0
10
0
0
10
0
0
10
0
37
0
0
% R
% Ser:
10
0
19
0
0
0
10
28
0
10
0
46
19
10
0
% S
% Thr:
0
37
19
0
0
0
0
37
10
0
10
10
10
0
0
% T
% Val:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _