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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EDC4
All Species:
20.61
Human Site:
S486
Identified Species:
45.33
UniProt:
Q6P2E9
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2E9
NP_055144.3
1401
151661
S486
P
A
E
E
E
N
D
S
L
G
A
D
G
T
H
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001089684
1300
138998
S440
H
G
A
G
A
M
E
S
A
A
G
V
L
I
K
Dog
Lupus familis
XP_546871
1484
160920
S571
P
A
E
E
E
N
D
S
L
G
A
D
G
T
H
Cat
Felis silvestris
Mouse
Mus musculus
Q3UJB9
1406
152465
S486
P
A
E
E
E
N
D
S
L
G
T
E
S
S
H
Rat
Rattus norvegicus
Q3ZAV8
1407
152577
S486
P
A
E
E
E
S
D
S
L
G
T
E
S
S
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_414022
1419
155974
N485
P
A
E
E
E
N
D
N
L
S
I
E
G
A
Q
Frog
Xenopus laevis
Q7ZXT3
1391
153901
S482
P
A
E
E
D
N
N
S
I
N
Q
E
E
I
L
Zebra Danio
Brachydanio rerio
Q1LUT1
1384
151831
S482
P
P
E
E
E
S
E
S
M
T
A
E
G
N
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKK1
1354
149232
N500
A
S
M
R
R
V
K
N
S
I
E
S
Y
Y
P
Honey Bee
Apis mellifera
XP_396550
1075
119372
T239
S
D
T
I
I
E
A
T
F
S
P
D
G
T
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784386
1287
142473
E439
E
L
Q
T
G
E
F
E
E
V
A
A
E
G
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
63.8
90.1
N.A.
94.8
94.4
N.A.
N.A.
74.3
62.4
61.6
N.A.
25.1
29.9
N.A.
32.9
Protein Similarity:
100
N.A.
70.2
91.5
N.A.
97
96.8
N.A.
N.A.
84.9
78.5
77.4
N.A.
45.4
48.1
N.A.
50.6
P-Site Identity:
100
N.A.
6.6
100
N.A.
73.3
66.6
N.A.
N.A.
60
40
46.6
N.A.
0
20
N.A.
6.6
P-Site Similarity:
100
N.A.
13.3
100
N.A.
86.6
86.6
N.A.
N.A.
73.3
66.6
73.3
N.A.
13.3
26.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
55
10
0
10
0
10
0
10
10
37
10
0
10
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
10
0
46
0
0
0
0
28
0
0
0
% D
% Glu:
10
0
64
64
55
19
19
10
10
0
10
46
19
0
10
% E
% Phe:
0
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% F
% Gly:
0
10
0
10
10
0
0
0
0
37
10
0
46
10
0
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
37
% H
% Ile:
0
0
0
10
10
0
0
0
10
10
10
0
0
19
0
% I
% Lys:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% K
% Leu:
0
10
0
0
0
0
0
0
46
0
0
0
10
0
10
% L
% Met:
0
0
10
0
0
10
0
0
10
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
46
10
19
0
10
0
0
0
10
0
% N
% Pro:
64
10
0
0
0
0
0
0
0
0
10
0
0
0
10
% P
% Gln:
0
0
10
0
0
0
0
0
0
0
10
0
0
0
19
% Q
% Arg:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
10
10
0
0
0
19
0
64
10
19
0
10
19
19
0
% S
% Thr:
0
0
10
10
0
0
0
10
0
10
19
0
0
28
0
% T
% Val:
0
0
0
0
0
10
0
0
0
10
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _