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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDC73
All Species:
14.24
Human Site:
S246
Identified Species:
26.11
UniProt:
Q6P1J9
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P1J9
NP_078805.3
531
60577
S246
Q
S
T
G
K
N
F
S
K
N
I
F
A
I
L
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001112520
355
40602
T106
P
V
D
P
T
L
R
T
K
Q
P
I
P
A
A
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
NP_666103
531
60558
S246
Q
S
T
G
K
N
F
S
K
N
I
F
A
I
L
Rat
Rattus norvegicus
Q4V8C8
531
60584
S246
Q
S
T
G
K
N
F
S
K
N
I
F
A
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516577
745
82627
A460
Q
S
T
G
K
N
F
A
K
N
I
F
A
I
L
Chicken
Gallus gallus
Q5ZLM0
531
60679
A246
Q
S
T
G
K
N
F
A
K
N
I
F
A
I
L
Frog
Xenopus laevis
NP_001079512
531
60663
A246
Q
S
T
G
K
N
F
A
K
N
I
F
A
I
L
Zebra Danio
Brachydanio rerio
NP_956642
521
59412
S245
Q
S
S
G
K
N
F
S
K
N
I
F
A
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649863
538
61366
A246
Q
S
T
G
K
I
F
A
K
N
I
F
A
M
L
Honey Bee
Apis mellifera
XP_395835
525
59540
A241
Q
S
S
G
K
I
F
A
K
N
I
F
A
I
L
Nematode Worm
Caenorhab. elegans
NP_500465
535
60290
L243
V
M
L
G
A
R
D
L
S
N
V
L
D
I
I
Sea Urchin
Strong. purpuratus
XP_001192448
532
61126
K249
R
S
N
G
K
E
F
K
N
I
F
A
I
L
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q06697
393
44438
V145
L
A
G
E
L
S
T
V
K
S
T
T
S
A
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
66.8
N.A.
N.A.
100
99.8
N.A.
67.6
97.7
93.9
88.8
N.A.
58.5
65.1
30.8
62.5
Protein Similarity:
100
N.A.
66.8
N.A.
N.A.
100
99.8
N.A.
70
98.6
96.6
92.6
N.A.
73.4
77.5
52.7
75.3
P-Site Identity:
100
N.A.
6.6
N.A.
N.A.
100
100
N.A.
93.3
93.3
93.3
93.3
N.A.
80
80
20
26.6
P-Site Similarity:
100
N.A.
13.3
N.A.
N.A.
100
100
N.A.
100
100
100
100
N.A.
93.3
93.3
33.3
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
39
0
0
0
8
70
16
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
8
0
0
0
0
0
8
0
0
% D
% Glu:
0
0
0
8
0
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
77
0
0
0
8
70
0
0
0
% F
% Gly:
0
0
8
85
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
16
0
0
0
8
70
8
8
70
8
% I
% Lys:
0
0
0
0
77
0
0
8
85
0
0
0
0
0
0
% K
% Leu:
8
0
8
0
8
8
0
8
0
0
0
8
0
8
70
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
8
0
0
54
0
0
8
77
0
0
0
0
0
% N
% Pro:
8
0
0
8
0
0
0
0
0
0
8
0
8
0
0
% P
% Gln:
70
0
0
0
0
0
0
0
0
8
0
0
0
0
8
% Q
% Arg:
8
0
0
0
0
8
8
0
0
0
0
0
0
0
0
% R
% Ser:
0
77
16
0
0
8
0
31
8
8
0
0
8
0
8
% S
% Thr:
0
0
54
0
8
0
8
8
0
0
8
8
0
0
0
% T
% Val:
8
8
0
0
0
0
0
8
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _