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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ISM2
All Species:
3.33
Human Site:
Y253
Identified Species:
8.15
UniProt:
Q6H9L7
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6H9L7
NP_872315.2
571
63906
Y253
W
S
F
L
W
G
D
Y
K
G
E
E
K
D
R
Chimpanzee
Pan troglodytes
XP_525268
582
65976
W276
W
S
V
P
S
P
D
W
R
A
W
W
Q
R
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542888
464
52096
S167
A
W
W
Q
R
S
L
S
L
T
R
A
N
S
G
Cat
Felis silvestris
Mouse
Mus musculus
A2ATD1
454
51126
S157
A
W
W
Q
R
S
L
S
L
A
R
T
N
S
G
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515088
433
49392
S135
R
N
W
W
Q
R
S
S
T
L
T
R
V
N
G
Chicken
Gallus gallus
XP_426452
491
55855
E194
N
M
D
V
G
D
R
E
E
E
E
D
E
E
D
Frog
Xenopus laevis
Q8QFV1
449
50956
T152
S
W
W
Q
R
S
A
T
L
P
R
M
N
Y
G
Zebra Danio
Brachydanio rerio
Q5EGE1
461
51157
V164
S
S
S
S
S
S
S
V
S
T
P
K
G
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_001120589
455
53322
Y157
N
K
T
K
E
E
D
Y
N
T
D
V
E
K
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001198390
398
44790
T101
G
K
S
N
L
D
I
T
I
E
V
V
T
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.4
N.A.
39.7
N.A.
38.3
N.A.
N.A.
37.1
46.9
37.4
38.1
N.A.
N.A.
24.3
N.A.
25.3
Protein Similarity:
100
46.7
N.A.
51.8
N.A.
51.1
N.A.
N.A.
48.1
59.8
50.9
51.3
N.A.
N.A.
40.4
N.A.
41.1
P-Site Identity:
100
20
N.A.
0
N.A.
0
N.A.
N.A.
0
6.6
0
6.6
N.A.
N.A.
13.3
N.A.
6.6
P-Site Similarity:
100
40
N.A.
6.6
N.A.
6.6
N.A.
N.A.
20
40
6.6
13.3
N.A.
N.A.
26.6
N.A.
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
20
0
0
0
0
0
10
0
0
20
0
10
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
0
20
30
0
0
0
10
10
0
20
30
% D
% Glu:
0
0
0
0
10
10
0
10
10
20
20
10
20
10
10
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
10
10
0
0
0
10
0
0
10
0
40
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
10
0
10
0
0
0
0
0
0
% I
% Lys:
0
20
0
10
0
0
0
0
10
0
0
10
10
10
0
% K
% Leu:
0
0
0
10
10
0
20
0
30
10
0
0
0
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
20
10
0
10
0
0
0
0
10
0
0
0
30
10
0
% N
% Pro:
0
0
0
10
0
10
0
0
0
10
10
0
0
10
0
% P
% Gln:
0
0
0
30
10
0
0
0
0
0
0
0
10
0
0
% Q
% Arg:
10
0
0
0
30
10
10
0
10
0
30
10
0
10
10
% R
% Ser:
20
30
20
10
20
40
20
30
10
0
0
0
0
20
10
% S
% Thr:
0
0
10
0
0
0
0
20
10
30
10
10
10
0
0
% T
% Val:
0
0
10
10
0
0
0
10
0
0
10
20
10
0
0
% V
% Trp:
20
30
40
10
10
0
0
10
0
0
10
10
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
20
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _