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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ISM2 All Species: 7.58
Human Site: S336 Identified Species: 18.52
UniProt: Q6H9L7 Number Species: 9
    Phosphosite Substitution
    Charge Score: -0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6H9L7 NP_872315.2 571 63906 S336 Q K E W S P W S P C S G N C S
Chimpanzee Pan troglodytes XP_525268 582 65976 C347 D W S L W S V C S V T C G N G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_542888 464 52096 S230 W S L W S V C S V T C G N G N
Cat Felis silvestris
Mouse Mus musculus A2ATD1 454 51126 S220 W S L W S V C S V T C G N G N
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515088 433 49392 C198 D W S P W S L C S A T C G G G
Chicken Gallus gallus XP_426452 491 55855 W257 D E E E W S P W S P C S I T C
Frog Xenopus laevis Q8QFV1 449 50956 S215 W S S W S V C S V T C G S G N
Zebra Danio Brachydanio rerio Q5EGE1 461 51157 S227 W S A W S P C S V S C G N G N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_001120589 455 53322 K220 W K R R D R S K K D K F T E S
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001198390 398 44790 V164 H H A P R R A V E E R E N E L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 32.4 N.A. 39.7 N.A. 38.3 N.A. N.A. 37.1 46.9 37.4 38.1 N.A. N.A. 24.3 N.A. 25.3
Protein Similarity: 100 46.7 N.A. 51.8 N.A. 51.1 N.A. N.A. 48.1 59.8 50.9 51.3 N.A. N.A. 40.4 N.A. 41.1
P-Site Identity: 100 0 N.A. 33.3 N.A. 33.3 N.A. N.A. 0 6.6 26.6 40 N.A. N.A. 13.3 N.A. 6.6
P-Site Similarity: 100 6.6 N.A. 40 N.A. 40 N.A. N.A. 6.6 13.3 40 46.6 N.A. N.A. 13.3 N.A. 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 20 0 0 0 10 0 0 10 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 40 20 0 10 50 20 0 10 10 % C
% Asp: 30 0 0 0 10 0 0 0 0 10 0 0 0 0 0 % D
% Glu: 0 10 20 10 0 0 0 0 10 10 0 10 0 20 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 50 20 50 20 % G
% His: 10 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % I
% Lys: 0 20 0 0 0 0 0 10 10 0 10 0 0 0 0 % K
% Leu: 0 0 20 10 0 0 10 0 0 0 0 0 0 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 50 10 40 % N
% Pro: 0 0 0 20 0 20 10 0 10 10 0 0 0 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 10 10 10 20 0 0 0 0 10 0 0 0 0 % R
% Ser: 0 40 30 0 50 30 10 50 30 10 10 10 10 0 20 % S
% Thr: 0 0 0 0 0 0 0 0 0 30 20 0 10 10 0 % T
% Val: 0 0 0 0 0 30 10 10 40 10 0 0 0 0 0 % V
% Trp: 50 20 0 50 30 0 10 10 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _