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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ARFGEF3 All Species: 30.61
Human Site: T1633 Identified Species: 67.33
UniProt: Q5TH69 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5TH69 NP_065073.3 2177 240652 T1633 L G C F H S G T E S F S G E G
Chimpanzee Pan troglodytes XP_518767 2177 240619 T1633 L G C F H S G T E S F S G E G
Rhesus Macaque Macaca mulatta XP_001095348 2107 232862 T1562 L G C F H S G T E S F S G E G
Dog Lupus familis XP_541124 2192 241439 T1636 L G C F H S G T E S F S G E G
Cat Felis silvestris
Mouse Mus musculus Q3UGY8 2170 240072 T1628 L G C F H G G T E G F S G E G
Rat Rattus norvegicus XP_218665 2170 240113 T1628 L G C F H S G T E G F S G E G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_419718 2177 241948 S1628 L G Y F H S G S E S F S G D A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_001921357 2181 240848 S1639 L A C F R S G S D S F T G D A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001096888 2070 230154 S1561 I E S P T K I S G S A T L A L
Honey Bee Apis mellifera XP_392019 2181 244055 F1631 L Q G P D S S F P S L S N V I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001193250 1550 170185 E1045 T I L L H G S E I Q V S G E H
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 95.7 93.1 N.A. 92.8 92 N.A. N.A. 84.8 N.A. 73.2 N.A. 22.8 32.4 N.A. 20.3
Protein Similarity: 100 99.9 96.2 96.1 N.A. 96 95.8 N.A. N.A. 92.4 N.A. 84.1 N.A. 41.4 52.6 N.A. 35.8
P-Site Identity: 100 100 100 100 N.A. 86.6 93.3 N.A. N.A. 73.3 N.A. 53.3 N.A. 6.6 26.6 N.A. 26.6
P-Site Similarity: 100 100 100 100 N.A. 86.6 93.3 N.A. N.A. 86.6 N.A. 80 N.A. 26.6 26.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 10 0 0 0 0 0 0 0 0 10 0 0 10 19 % A
% Cys: 0 0 64 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 10 0 0 0 10 0 0 0 0 19 0 % D
% Glu: 0 10 0 0 0 0 0 10 64 0 0 0 0 64 0 % E
% Phe: 0 0 0 73 0 0 0 10 0 0 73 0 0 0 0 % F
% Gly: 0 64 10 0 0 19 73 0 10 19 0 0 82 0 55 % G
% His: 0 0 0 0 73 0 0 0 0 0 0 0 0 0 10 % H
% Ile: 10 10 0 0 0 0 10 0 10 0 0 0 0 0 10 % I
% Lys: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % K
% Leu: 82 0 10 10 0 0 0 0 0 0 10 0 10 0 10 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % N
% Pro: 0 0 0 19 0 0 0 0 10 0 0 0 0 0 0 % P
% Gln: 0 10 0 0 0 0 0 0 0 10 0 0 0 0 0 % Q
% Arg: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 10 0 0 73 19 28 0 73 0 82 0 0 0 % S
% Thr: 10 0 0 0 10 0 0 55 0 0 0 19 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 10 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _