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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ARFGEF3
All Species:
22.73
Human Site:
S77
Identified Species:
50
UniProt:
Q5TH69
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5TH69
NP_065073.3
2177
240652
S77
A
G
M
Q
K
L
L
S
E
E
R
F
V
S
M
Chimpanzee
Pan troglodytes
XP_518767
2177
240619
S77
A
G
M
Q
K
L
L
S
E
E
R
F
V
S
M
Rhesus Macaque
Macaca mulatta
XP_001095348
2107
232862
L65
D
L
N
G
S
A
V
L
K
I
A
E
V
C
I
Dog
Lupus familis
XP_541124
2192
241439
S77
A
G
I
Q
K
L
L
S
E
E
R
F
V
S
M
Cat
Felis silvestris
Mouse
Mus musculus
Q3UGY8
2170
240072
S77
A
G
M
Q
K
L
L
S
E
E
R
F
V
S
M
Rat
Rattus norvegicus
XP_218665
2170
240113
S77
A
G
M
Q
K
L
L
S
E
E
R
F
V
S
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419718
2177
241948
S77
A
G
M
Q
K
L
L
S
D
E
R
F
V
S
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001921357
2181
240848
C77
T
G
M
Q
K
I
L
C
E
D
C
F
L
A
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001096888
2070
230154
R74
M
G
L
N
G
L
H
R
V
I
K
D
E
R
F
Honey Bee
Apis mellifera
XP_392019
2181
244055
A66
T
K
R
S
K
F
V
A
F
G
L
S
G
L
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001193250
1550
170185
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
95.7
93.1
N.A.
92.8
92
N.A.
N.A.
84.8
N.A.
73.2
N.A.
22.8
32.4
N.A.
20.3
Protein Similarity:
100
99.9
96.2
96.1
N.A.
96
95.8
N.A.
N.A.
92.4
N.A.
84.1
N.A.
41.4
52.6
N.A.
35.8
P-Site Identity:
100
100
6.6
93.3
N.A.
100
100
N.A.
N.A.
86.6
N.A.
46.6
N.A.
13.3
6.6
N.A.
0
P-Site Similarity:
100
100
26.6
100
N.A.
100
100
N.A.
N.A.
100
N.A.
80
N.A.
26.6
20
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
55
0
0
0
0
10
0
10
0
0
10
0
0
10
0
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
10
0
0
10
0
% C
% Asp:
10
0
0
0
0
0
0
0
10
10
0
10
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
55
55
0
10
10
0
0
% E
% Phe:
0
0
0
0
0
10
0
0
10
0
0
64
0
0
10
% F
% Gly:
0
73
0
10
10
0
0
0
0
10
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
10
0
0
10
0
0
0
19
0
0
0
0
10
% I
% Lys:
0
10
0
0
73
0
0
0
10
0
10
0
0
0
0
% K
% Leu:
0
10
10
0
0
64
64
10
0
0
10
0
10
10
0
% L
% Met:
10
0
55
0
0
0
0
0
0
0
0
0
0
0
46
% M
% Asn:
0
0
10
10
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
64
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
0
0
0
10
0
0
55
0
0
10
0
% R
% Ser:
0
0
0
10
10
0
0
55
0
0
0
10
0
55
0
% S
% Thr:
19
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
19
0
10
0
0
0
64
0
19
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _