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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: WLS All Species: 30.91
Human Site: S260 Identified Species: 61.82
UniProt: Q5T9L3 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5T9L3 NP_001002292.1 541 62253 S260 W R R I T M M S R P P V L L E
Chimpanzee Pan troglodytes XP_001164915 432 50033 L164 L E K V I F A L G I S M T F I
Rhesus Macaque Macaca mulatta XP_001095839 305 35297 A36 L L E K V I F A L G I S M T F
Dog Lupus familis XP_853835 541 62057 S260 W R R I T M M S R P P V L L E
Cat Felis silvestris
Mouse Mus musculus Q6DID7 541 62170 S260 W R R I T M M S R P P V L L E
Rat Rattus norvegicus Q6P689 541 62184 S260 W R R I T M M S R P P V L L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513709 541 62387 T260 W R R I T M M T R P P V L L E
Chicken Gallus gallus Q5ZLR1 541 62119 T260 W R R I T L M T R A P V L L E
Frog Xenopus laevis Q66IZ4 541 61893 T260 W R R I T M M T R S P V L L E
Zebra Danio Brachydanio rerio NP_998311 542 62075 T261 W K R I T Q M T R P P V L L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95ST2 594 67871 Q267 W R R V H L L Q R S P A L L E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_785250 568 65141 A282 W K R I V Q L A R P P V L L E
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79.4 56.1 96.3 N.A. 96.1 95.7 N.A. 92.7 87.8 75 78 N.A. 40.9 N.A. N.A. 46.4
Protein Similarity: 100 79.6 56.3 98.1 N.A. 97.9 98.1 N.A. 97 94.6 86.1 88.3 N.A. 60.6 N.A. N.A. 63.2
P-Site Identity: 100 0 0 100 N.A. 100 100 N.A. 93.3 80 86.6 80 N.A. 53.3 N.A. N.A. 66.6
P-Site Similarity: 100 20 20 100 N.A. 100 100 N.A. 100 93.3 93.3 93.3 N.A. 73.3 N.A. N.A. 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 9 17 0 9 0 9 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 9 9 0 0 0 0 0 0 0 0 0 0 0 84 % E
% Phe: 0 0 0 0 0 9 9 0 0 0 0 0 0 9 9 % F
% Gly: 0 0 0 0 0 0 0 0 9 9 0 0 0 0 0 % G
% His: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 75 9 9 0 0 0 9 9 0 0 0 9 % I
% Lys: 0 17 9 9 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 17 9 0 0 0 17 17 9 9 0 0 0 84 84 0 % L
% Met: 0 0 0 0 0 50 67 0 0 0 0 9 9 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 59 84 0 0 0 0 % P
% Gln: 0 0 0 0 0 17 0 9 0 0 0 0 0 0 0 % Q
% Arg: 0 67 84 0 0 0 0 0 84 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 34 0 17 9 9 0 0 0 % S
% Thr: 0 0 0 0 67 0 0 34 0 0 0 0 9 9 0 % T
% Val: 0 0 0 17 17 0 0 0 0 0 0 75 0 0 0 % V
% Trp: 84 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _