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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MANEA All Species: 22.42
Human Site: S398 Identified Species: 49.33
UniProt: Q5SRI9 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q5SRI9 NP_078917.2 462 53671 S398 Q T R P S L I S I T S F N E W
Chimpanzee Pan troglodytes XP_527453 577 66263 S513 Q T R P S L I S I T S F N E W
Rhesus Macaque Macaca mulatta XP_001096615 577 65849 S513 Q T H P S L I S I T S F N E W
Dog Lupus familis XP_539046 478 55693 S414 H A H P S I I S I T S F N E W
Cat Felis silvestris
Mouse Mus musculus Q6NXH2 462 53165 S398 Q T H P S L I S I T S F N E W
Rat Rattus norvegicus Q5GF25 462 53398 S398 Q T Q P S L I S I T S F N E W
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506704 456 52289 L392 A A L S A A L L V R P Q V I S
Chicken Gallus gallus XP_419831 457 52792 L393 T A F N A A L L V R P E I I S
Frog Xenopus laevis Q6DE40 449 51843 V386 A I N A A L L V R P K I I S I
Zebra Danio Brachydanio rerio Q1L8D2 442 50295 V379 S L Q A A M S V R P D I I T I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_796542 491 57060 S426 D G D Y Y D R S L Q A A V K V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 78.1 82.4 N.A. 85.5 85.5 N.A. 70.5 70.5 64.9 54.9 N.A. N.A. N.A. N.A. 45.2
Protein Similarity: 100 79 79 89.3 N.A. 92.6 92.6 N.A. 81.1 80.5 79 73.5 N.A. N.A. N.A. N.A. 63.1
P-Site Identity: 100 100 93.3 73.3 N.A. 93.3 93.3 N.A. 0 0 6.6 0 N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: 100 100 93.3 80 N.A. 93.3 100 N.A. 20 20 20 20 N.A. N.A. N.A. N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 19 28 0 19 37 19 0 0 0 0 10 10 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 10 0 10 0 0 10 0 0 0 0 10 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 10 0 55 0 % E
% Phe: 0 0 10 0 0 0 0 0 0 0 0 55 0 0 0 % F
% Gly: 0 10 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 10 0 28 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 10 0 0 0 10 55 0 55 0 0 19 28 19 19 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 10 0 0 10 0 % K
% Leu: 0 10 10 0 0 55 28 19 10 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 10 10 0 0 0 0 0 0 0 0 55 0 0 % N
% Pro: 0 0 0 55 0 0 0 0 0 19 19 0 0 0 0 % P
% Gln: 46 0 19 0 0 0 0 0 0 10 0 10 0 0 0 % Q
% Arg: 0 0 19 0 0 0 10 0 19 19 0 0 0 0 0 % R
% Ser: 10 0 0 10 55 0 10 64 0 0 55 0 0 10 19 % S
% Thr: 10 46 0 0 0 0 0 0 0 55 0 0 0 10 0 % T
% Val: 0 0 0 0 0 0 0 19 19 0 0 0 19 0 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 55 % W
% Tyr: 0 0 0 10 10 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _