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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D4B
All Species:
28.18
Human Site:
Y235
Identified Species:
62
UniProt:
Q5SQS7
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5SQS7
NP_001139191.1
431
51232
Y235
A
Q
R
A
R
D
E
Y
R
H
H
S
L
R
A
Chimpanzee
Pan troglodytes
XP_521531
433
51331
Y236
A
Q
R
A
R
D
E
Y
R
R
H
S
L
R
A
Rhesus Macaque
Macaca mulatta
XP_001087259
433
51270
Y236
A
Q
R
A
R
D
E
Y
R
R
H
S
L
R
A
Dog
Lupus familis
XP_536404
488
56564
Y292
A
Q
R
A
R
D
E
Y
R
R
H
S
L
R
A
Cat
Felis silvestris
Mouse
Mus musculus
A6X942
431
51101
Y235
A
Q
R
A
R
D
E
Y
R
R
H
S
L
R
A
Rat
Rattus norvegicus
Q6AYC8
422
48504
Y229
A
K
Q
A
R
E
D
Y
K
R
L
S
Q
R
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507607
587
66688
H392
A
R
W
A
R
A
E
H
Q
R
H
S
F
R
A
Chicken
Gallus gallus
XP_001232928
425
50516
Y234
A
R
R
A
R
D
E
Y
R
R
Q
S
L
R
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_689048
423
49636
Y227
A
R
R
A
R
D
E
Y
K
R
Q
S
L
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_741483
533
60879
R299
E
A
E
I
M
E
D
R
Q
N
P
D
W
E
E
Sea Urchin
Strong. purpuratus
XP_781629
470
56428
I266
D
R
S
H
R
A
K
I
A
R
E
E
V
R
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.6
96.3
68.4
N.A.
92.1
42.6
N.A.
54.1
71.9
N.A.
61.4
N.A.
N.A.
N.A.
27.9
38.9
Protein Similarity:
100
98.8
97.2
75.6
N.A.
95.5
61.4
N.A.
60.8
83.5
N.A.
76
N.A.
N.A.
N.A.
43.3
57.8
P-Site Identity:
100
93.3
93.3
93.3
N.A.
93.3
40
N.A.
53.3
80
N.A.
73.3
N.A.
N.A.
N.A.
0
13.3
P-Site Similarity:
100
93.3
93.3
93.3
N.A.
93.3
73.3
N.A.
73.3
86.6
N.A.
86.6
N.A.
N.A.
N.A.
26.6
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
82
10
0
82
0
19
0
0
10
0
0
0
0
0
73
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
64
19
0
0
0
0
10
0
0
0
% D
% Glu:
10
0
10
0
0
19
73
0
0
0
10
10
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% G
% His:
0
0
0
10
0
0
0
10
0
10
55
0
0
0
0
% H
% Ile:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
0
0
0
10
0
19
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
10
0
64
0
0
% L
% Met:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% P
% Gln:
0
46
10
0
0
0
0
0
19
0
19
0
10
0
0
% Q
% Arg:
0
37
64
0
91
0
0
10
55
82
0
0
0
91
10
% R
% Ser:
0
0
10
0
0
0
0
0
0
0
0
82
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% V
% Trp:
0
0
10
0
0
0
0
0
0
0
0
0
10
0
0
% W
% Tyr:
0
0
0
0
0
0
0
73
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _