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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EARS2
All Species:
39.7
Human Site:
Y261
Identified Species:
72.78
UniProt:
Q5JPH6
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q5JPH6
NP_001077083.1
523
58689
Y261
T
A
K
H
L
L
L
Y
Q
A
L
G
W
Q
P
Chimpanzee
Pan troglodytes
XP_001162700
523
58613
Y261
T
A
K
H
L
L
L
Y
Q
A
L
G
W
Q
P
Rhesus Macaque
Macaca mulatta
XP_001094523
523
58733
Y261
T
A
K
H
L
L
L
Y
Q
A
L
G
W
H
P
Dog
Lupus familis
XP_536934
523
58363
Y261
T
S
K
H
L
L
L
Y
Q
A
L
G
W
Q
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9CXJ1
523
58308
Y261
T
S
K
H
L
L
L
Y
Q
A
L
G
W
Q
P
Rat
Rattus norvegicus
NP_001152965
523
58243
Y261
T
S
K
H
L
L
L
Y
Q
A
L
G
W
Q
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q5ZJ66
502
56936
Y240
T
S
K
H
L
L
L
Y
K
A
F
G
W
D
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Q0P499
503
57005
Y242
S
A
K
H
L
Q
L
Y
R
A
L
R
W
T
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648894
511
58491
Y245
T
T
K
H
L
L
L
Y
K
A
F
G
W
Q
P
Honey Bee
Apis mellifera
XP_395175
370
42856
V164
L
N
S
N
E
V
K
V
K
L
N
N
G
D
P
Nematode Worm
Caenorhab. elegans
NP_499917
481
55781
Y233
T
G
K
H
T
I
L
Y
K
A
F
N
W
T
P
Sea Urchin
Strong. purpuratus
XP_788628
270
30715
R64
L
G
G
K
F
I
L
R
I
E
D
T
D
Q
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P48525
536
61585
Y268
T
P
K
H
I
A
L
Y
N
A
F
G
W
A
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
94.2
86
N.A.
85
84.8
N.A.
N.A.
65.7
N.A.
57.1
N.A.
47.4
34.7
37.2
28.6
Protein Similarity:
100
99.6
96.9
92.9
N.A.
92.3
92.3
N.A.
N.A.
79.3
N.A.
71.8
N.A.
64.6
50.2
55.2
38
P-Site Identity:
100
100
93.3
93.3
N.A.
93.3
93.3
N.A.
N.A.
73.3
N.A.
66.6
N.A.
80
6.6
53.3
13.3
P-Site Similarity:
100
100
93.3
100
N.A.
100
100
N.A.
N.A.
86.6
N.A.
80
N.A.
86.6
26.6
66.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
35.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
31
0
0
0
8
0
0
0
85
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
8
0
8
16
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
31
0
0
0
0
% F
% Gly:
0
16
8
0
0
0
0
0
0
0
0
70
8
0
0
% G
% His:
0
0
0
85
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
8
16
0
0
8
0
0
0
0
0
0
% I
% Lys:
0
0
85
8
0
0
8
0
31
0
0
0
0
0
0
% K
% Leu:
16
0
0
0
70
62
93
0
0
8
54
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
8
0
0
0
0
8
0
8
16
0
0
0
% N
% Pro:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
85
% P
% Gln:
0
0
0
0
0
8
0
0
47
0
0
0
0
54
0
% Q
% Arg:
0
0
0
0
0
0
0
8
8
0
0
8
0
0
0
% R
% Ser:
8
31
8
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
77
8
0
0
8
0
0
0
0
0
0
8
0
16
8
% T
% Val:
0
0
0
0
0
8
0
8
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
85
0
0
% W
% Tyr:
0
0
0
0
0
0
0
85
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _